Skip to main content
SpringerLink
Log in

EPR Signals Detectable in Human Tumors

  • Chapter
Nitric Oxide in Transplant Rejection and Anti-Tumor Defense

  • 85 Accesses

Abstract

Interpretation of EPR signals seen in animal tumors changed over the years, as described in chapter 20. Basing on previous EPR observations with animal neoplasms and on theoretical considerations, attention has been focused in the present work on five types of paramagnetic centers, which either have been detected in the past in animal tumors or could be expected to exist in this kind of material:

  1. 1.

    EPR “triplet” signals due to iron-nitrosyl heme complexes,

  2. 2.

    EPR spectra of ceruloplasmin and related compounds,

  3. 3.

    EPR signals associated with the presence of melanin in pigmented tumors,

  4. 4.

    Single line signals attributable to free radicals of metabolic origin,

  5. 5.

    Single line signals originating from incidental contamination with solid carbon present in the air or food.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Brennan MJ, Cole T, Singley JA, A unique hyperfine ESR spectrum in mouse neoplasms analysed by computer simulation. Proc Soc Exp Biol Med 1966; 123:715–717

    PubMed  CAS  Google Scholar 

  • Brill AS, Bryce GF, Cupric ion in blue proteins. J Chem Phys 1968;48:4399–4404

    Article  Google Scholar 

  • Commoner B, Thownsend J, Pake GE, Free radicals in biological materials. Nature 1954; 4432:689–691

    Article  Google Scholar 

  • Czaja K, EPR prognostic tests based on studying human tumor tissue biopsies. MSc thesis (in Polish), Jagiellonian University, Krakow. 1997

    Google Scholar 

  • Doi K et al., Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth. Cancer 1996;77:1598–1604

    PubMed  CAS  Google Scholar 

  • Foster MA, Magnetic Resonance in Medicine and Biology. Pergamon Press, Oxford. 1984

    Google Scholar 

  • Foster MA, Dawson AA, Pocklington T, Fell L, Eelctron spin resonance measurements of blood caeruloplasmin and iron transferrin levels in patients with non-Hodgkin lymphoma. Clin Radiol 1977a;, 28:23–28

    Google Scholar 

  • Foster MA, Fell L, Pocklington T, Akinsete F, Dawson AA, Hutchinson JMS, Mallard JR, Electron spin resonance as a useful technique in the management of Hodgkin disease. Clin Radiol 1977b;28:15–22

    Google Scholar 

  • Foster MA, Pocklington T, Miller JDB, Mallard JR, A study of electron spin resonance spectra of whole blood from normal and tumor bearing patients. Br J Cancer 1973;28:340–348

    Article  PubMed  CAS  Google Scholar 

  • Horn RA, Friesen EJ, Stephens RL, Hendrick WR, Zimbrick JD, Electron spin resonance studies on properties of ceruloplasmin and transferrin in blood from normal human subjects and cancer patients. Cancer 1979;43:2392–2398

    Article  PubMed  CAS  Google Scholar 

  • Hughes NR, Serum transferrin and caeruloplasmin concentration in patients with carcinoma, melanoma, sarcoma and cancers of haematopoietic tissues. Aust J Exp Biol Med Sci 1972;50:97

    Google Scholar 

  • Joshi M, The importance of L-arginine metabolism in melanoma: an hypohesis for the role of nitric oxide and polyamines in tumor angiogenesis. Free Rad Biol Med 1997;22(3):573–578

    Google Scholar 

  • Joshi M, Strandhoy J, White WL, Nitric oxide synthase activity is up-regulated in melanoma cell lines: a potential mechanism for matestases formation. Melanoma Res 1996;6:121–126

    Article  PubMed  CAS  Google Scholar 

  • Kriska T, Mal’tseva E, Gal D, In vivo experimental studies on the role of free radicals in photodynamic therapy. II, Photodynamic effect on free radical concetration in mice tumors measured by ESR spectroscopy. Biochem Biophys Res Commun 1996;223:136–140

    Google Scholar 

  • Lancaster JR Jr, Hibbs JB, EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc Natl Acad Sci USA 1990;87:1223–1227

    Article  PubMed  CAS  Google Scholar 

  • Lukiewicz SJ, Plonka P, ESR technique as a method of detecting immune-host interactions. Proc Soc Magnet Reson 1994;2:730

    Google Scholar 

  • Mallard JR, Kent M, Electron spin resonance in biological tissues. Phys Med Biol 1969; 14:373–396

    Article  PubMed  CAS  Google Scholar 

  • Maruyama T et al., Identification of three-line electron spin resonance signal and its relationship to ascites tumors. Cancer Res 1971;31:179–184

    PubMed  CAS  Google Scholar 

  • Plonka BK et al., ESR signals detectable in the tumors of murine L5178Y-R lymphoma. Curr Top Biophys 1996;20(l):81–85

    CAS  Google Scholar 

  • Plonka PM et al., ESR studies on the generation of nitric oxide in rejecting rat heart allografts and in situ growing tumors. Curr Top Bioph 1996;20(l):46–52

    Google Scholar 

  • Pocklington T, Foster MA, Electron spin resonance of caeruloplasmin and iron transferrin in blood of patients with various malignant diseases. Br J Cancer 1977;36:369–374

    Article  PubMed  CAS  Google Scholar 

  • Pocklington T, Foster MA, Mallard JR, Plasma total iron-binding capacity measured by electron spin resonance. Phys Med Biol 1977;22:98–102

    Article  PubMed  CAS  Google Scholar 

  • Renoux G, Renoux M, Lemarie E, Lavandier M, Greco J, Bardos P, Lang JM, Boilletot A, Oberling F, Armand J, Musset A, Biron G. Sodium diethyldithiocarbamate (imuthiol) and cancer. Adv Exp Med Biol 1983;166:223–239

    Article  PubMed  CAS  Google Scholar 

  • Roitt I, Brostoff J, Male D, Immunology, 4th ed., Mosby-Wolfe, London. 1996

    Google Scholar 

  • Ruzicka FJ, Beinert H, Schepler KL, Dunham RW, Sands RH, Interaction of ubisemiquinone with a paramagnetic component in heart tissue. Proc Natl Acad Sci USA 197572(8):2886–2890

    Google Scholar 

  • Slater TF, Cook JWR, Electron spin resonance studies on normal and malignant human tissues and in normal and damaged rat liver. In Evans DMD ed. Cytology Automation. Livingstone Press, London. 1970,108–120

    Google Scholar 

  • Shulyakovskaya T, Sumegi L, Gal D, In vivo experimental studies on the role of free radicals in photodynamic therapy. I. Measurement of the steady state concentration of free radicals in tumor tissues in mice. Biochem Biophys Res Commun 1993; 195:581–587

    Article  PubMed  CAS  Google Scholar 

  • Thomsen LL, Lawton FG, Knowles RG, Beesley JE, Rivero J, Moreno V, Moncada S. Nitric oxide synthase activity in human gynecological cancer. Cancer Res 1994;54:1352–1354

    PubMed  CAS  Google Scholar 

  • Thomsen LL, Miles DW, Happerfield L, Bobrow LG, Knowles RG, Moncada S. Nitric oxide synthase activity in human breast cancer. British J Cancer 1995;72:41–44

    Article  CAS  Google Scholar 

  • Wennmalm A, Lanue B, Petersson AM. Detection of endothclial-derived relaxing factor in human plasma in the basal state and following ischemia using electron paramagnetic resonance spectroscopy. Anal Biochem 1990;187:359–363

    Article  PubMed  CAS  Google Scholar 

  • Yukawa M, Onodera T, Suzuki JK, Yokomizo Y, Suzuki M, Mochizuki K, Impairment of macrophage function in mongolian gerbils. Vet Immunol Immunopathol 1992;33:353–364

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Radiospectroscopy of Cancer and Radiobiology, Department of Biophysics, Jagiellonian University, Institute of Molecular Biology, Al. Mickiewicza 3, 31-120, Krakow, Poland

    Stanislaw Lukiewicz, Martyna Elas, Jolanta Raczek, Anna Bratasz, Stanislawa Pajak & Krystyna Cieszka

Authors
  1. Stanislaw Lukiewicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martyna Elas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jolanta Raczek
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anna Bratasz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Stanislawa Pajak
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Krystyna Cieszka
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Jagiellonian University, Poland

    Stanislaw Lukiewicz

  2. Johns Hopkins University School of Medicine, USA

    Jay L. Zweier

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Lukiewicz, S., Elas, M., Raczek, J., Bratasz, A., Pajak, S., Cieszka, K. (1998). EPR Signals Detectable in Human Tumors. In: Lukiewicz, S., Zweier, J.L. (eds) Nitric Oxide in Transplant Rejection and Anti-Tumor Defense. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5081-5_23

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-5081-5_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7311-7

  • Online ISBN: 978-1-4615-5081-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation