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Involvement of Nitric Oxide in Amphibian Transplantation Immunity

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Nitric Oxide in Transplant Rejection and Anti-Tumor Defense

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Abstract

Nitric oxide (NO), a highly reactive nonpolar gas, is one of the crucial molecules in the neural (Goldstein et al., 1996; Iadecola, 1997), vascular (Bassenge, 1996; Busse et al., 1995), and immune (Liew, 1995; Salkowski et al., 1997) systems. NO generation in eukaryotes is catalyzed by evolutionary conserved enzymes referred to as nitric oxide synthases (NOS), constitutive (cNOS) or inducible (iNOS). The cNOSs are constitutively expressed by certain neuronal and epithelial cells, where they act as neurotransmitters and blood pressure regulators, respectively. In macrophages and many other immunocompetent cells, iNOS expression is induced by cytokines or other activators (Nathan, 1995; Schmidt et al., 1995) in a species-specific manner (Jungi et al., 1996).

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  1. Department of Evolutionary Immunology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30-060, Kraków, Poland

    Alicja Jozkowicz & Barbara Plytycz

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  1. Alicja Jozkowicz
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Editors and Affiliations

  1. The Jagiellonian University, Poland

    Stanislaw Lukiewicz

  2. Johns Hopkins University School of Medicine, USA

    Jay L. Zweier

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Jozkowicz, A., Plytycz, B. (1998). Involvement of Nitric Oxide in Amphibian Transplantation Immunity. In: Lukiewicz, S., Zweier, J.L. (eds) Nitric Oxide in Transplant Rejection and Anti-Tumor Defense. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5081-5_13

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  • DOI: https://doi.org/10.1007/978-1-4615-5081-5_13

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