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The Interaction of Cytokines with Stem Cell and Stromal Cell Physiology

  • Chapter
Clinical Applications of Cytokines and Growth Factors

Part of the book series: Developments in Oncology ((DION,volume 80))

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Abstract

It is now well established that cellular interactions between primitive haemopoietic progenitor cells (HPC) and the stromal tissue of the bone marrow (BM) play a central role in regulating haemopoiesis. Despite considerable research efforts, the precise molecular mechanisms responsible for this control remain to be fully defined. Nevertheless, from these studies has emerged the general consensus that at least two classes of molecules including haemopoietic growth factors (HGF) and members of several cell adhesion molecule (CAM) superfamilies contribute to the regulation of haemopoiesis although the exact contribution made by each class of molecule remains to be determined. There are abundant data derived from studies performed in vitro and in vivo demonstrating HGF as potent regulators of HPC survival, growth and differentiation. The exact contribution made by CAMs is less well understood but emerging evidence derived from studies performed both in the haemopoietic and other systems clearly demonstrate that in addition to their well documented pro-adhesive functions, CAMs, like cytokine receptors, are also signalling molecules. Such observations therefore support the notion that in addition to their well documented role in initiating and maintaining contact between HPC and stromal cells, CAMs may also participate more directly in the growth and development of primitive HPC. In support of this proposal are recent data which demonstrate the considerable functional overlap and interdependence between the HGF and CAM families as demonstrated, for example, by the capacity of HGF to regulate the functional properties of CAMs on primitive HPC.

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  1. Paul J. Simmons
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  2. David N. Haylock
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  3. Jean-Pierre Levesque
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  4. Andrew C. W. Zannettino
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  1. Bone Marrow Transplant Program, Division of Hematology/Oncology, University of Florida College of Medicine, Shands Hospital, Gainesville, FL, 32610, USA

    John R. Wingard M.D. (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Adult Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02115, USA

    George D. Demetri M.D. (Assistant Professor of Medicine) (Assistant Professor of Medicine)

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© 1999 Springer Science+Business Media New York

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Simmons, P.J., Haylock, D.N., Levesque, JP., Zannettino, A.C.W. (1999). The Interaction of Cytokines with Stem Cell and Stromal Cell Physiology. In: Wingard, J.R., Demetri, G.D. (eds) Clinical Applications of Cytokines and Growth Factors. Developments in Oncology, vol 80. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5013-6_2

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  • DOI: https://doi.org/10.1007/978-1-4615-5013-6_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7277-6

  • Online ISBN: 978-1-4615-5013-6

  • eBook Packages: Springer Book Archive

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