Skip to main content

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 217))

  • 92 Accesses

Abstract

The human body has the immune system to recognize substances which do not belong to it and produces against them, compounds called“antibodies”. People may form antibodies against substances of their own (“autoantibodies”), giving birth to various clinical syndromes. Although the mechanisms are not yet clearly understood, clinical and experimental data support the suggestion that autoimmune mechanisms play a significant role in the pathogenesis of heart diseases as myocarditis and dilated cardiomyopathy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 299.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 379.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Manolio TA, et al. Prevalence and etiology of idiopathic dilated cardiomyopathy. Am J Cardiol 1992: 69: 1458.

    Article  PubMed  CAS  Google Scholar 

  2. MacArthur CGC, et al. The relationship of myocarditis to dilated cardiomyopathy. Eur Heart J 1984: 5: 1023.

    PubMed  CAS  Google Scholar 

  3. Huber SA, Lyden DC, Lodge PA. Myocarditis. Herz 1985: 10: 1.

    PubMed  CAS  Google Scholar 

  4. McManus BM, Gauntt CJ, Cassling RS. Immunopathologic basis of myocardial injury. Cardiovasc Clin 1988: 18: 163.

    PubMed  CAS  Google Scholar 

  5. Zee-Cheng CS, et al. High incidence of myocarditis by endomyocardial biopsy in patients with idiopathic congestive cardiomyopathy. J Am Coll Cardiol 1984: 3: 63.

    Article  PubMed  CAS  Google Scholar 

  6. Bowles NE, et al. Detection of coxsackie B virus specific TNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy. Lancet 1988: 1: 1120.

    Google Scholar 

  7. Tazelaar HD, Billingham ME. Leukocytic infiltrates in idiopathic dilated cardiomyopathy. Am J Surg Pathol 1986: 10: 405.

    Article  PubMed  CAS  Google Scholar 

  8. Grodums EL, Dempster G. Myocarditis in experimental coxsackie B3 infection. Con J Microbiol 1959: 5: 605.

    Article  CAS  Google Scholar 

  9. Wolfgram LJ, et al. Variation in the susceptibility to coxsackie virus B3-induced myocarditis among different strains of mice. J Immunol 1986: 136: 1846.

    PubMed  CAS  Google Scholar 

  10. Schwimmbeck PL, Shyltheiss HP, Strauer BE. Isolation of myocardial antibodies using imunoabsorption with synthetic peptides as antigens. Eur Heart J 1990: 280: 463.

    Google Scholar 

  11. Wolfgram LJ, Beisel KW, Rose NR. Heart specific autoantibodies following murine coxsackie B3 myocarditis. J Exp Med 1985: 161: 112.

    Article  Google Scholar 

  12. Alvarez FL, et al. Heart specific autoantibodies induced by coxsackie-virus B3 identification of heart autoantigens. Clin Immunol Immunopathol 1987: 43: 129.

    Article  PubMed  CAS  Google Scholar 

  13. Neu N, et al. Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to coxsackievirus B3-induced myocarditis. J Immunol 1987: 138: 2488.

    PubMed  CAS  Google Scholar 

  14. Lauer B, et al. Autoantibodies against human ventricular myosin in sera of patients with acute and chronic myocarditis. J Am Coll Cardiol 1994: 23: 146.

    Article  PubMed  CAS  Google Scholar 

  15. Caforio ALP, et al. Identification of a and b cardiac myosin heavy chain isoforms as major autoantigens. Circulation 1992: 85: 1734.

    Article  PubMed  CAS  Google Scholar 

  16. Konstadoulakis MM, et al. Clinical significance of antibodies against tropomyosin, actin and myosin in patients with dilated cardiomyopathy. J Clin Lab Immunol 1993: 40: 61.

    PubMed  CAS  Google Scholar 

  17. Neumann DA, et al. Induction of multiple heart autoantibodies in mice with coxsackievirus B3 and cardiac myosin induced autoimmune myocarditis. J Immunol 1994: 152: 343.

    PubMed  CAS  Google Scholar 

  18. Limas CJ, Goldenberg IF, Limas C. Autoantibodies against b-adrenoreceptors in human idiopathic dilated cardiomyopathy. Circ Res 1989: 64: 97.

    Article  PubMed  CAS  Google Scholar 

  19. Goldman JH, et al. Autoimmunity to a-myosin in a subset of patients with idiopathic dilated cardiomyopathy. Br Heart J 1995: 74: 598.

    Article  PubMed  CAS  Google Scholar 

  20. Herskowitz A, Neumann DA, Ansari AA. Concepts of autoimmunity applied to dilate cardiomyopathy. J Am Coll Cardiol 1993: 22: 1385.

    Article  PubMed  CAS  Google Scholar 

  21. Limas Cath, et al. Anti-b-receptor antibodies in familiar cardiomyopathy: Correlation with HLA-DR and HLA-DQ gene polymorphisms. Am Heart J 1994: 127: 382.

    Article  PubMed  CAS  Google Scholar 

  22. Magnusson Y, et al. Autoimmunity in idiopathic dilated cardiomyopathy. Circulation 1994: 89: 2760.

    Article  PubMed  CAS  Google Scholar 

  23. Kuhl U, Ulrich G, Schultheib H-P. Cross-reactivity of antibodies to the ADP/ATP translocator to the inner mitochondrial membrane with the cell surface of cardiac myocytes. Eur Heart J 1987: 8 (Suppl.l): 219.

    Article  Google Scholar 

  24. Holzinger C, et al. Phenotypic patterns of mononuclear cells in dilated cardiomyopathy. Circulation 1995: 92: 2876.

    Article  PubMed  CAS  Google Scholar 

  25. Anderson JL, et al. Immunosuppressive therapy of myocardial inflammatory disease. Initial experience and future trials to define indications for therapy. Eur Heart J 1987: 8(Suppl.): 263.

    Article  Google Scholar 

  26. Robinson JH, Kehor MA. Group A streptococcal M proteins: virulence factors and protective antigens. Immunol. Today 1992: 13: 362.

    Article  PubMed  CAS  Google Scholar 

  27. Dell A, et al. Autoimmune determinants of rheumatic carditis localization of epitopes in human cardiac myosin. Eur Heart J 1991: 12(Suppl.D): 158.

    Article  PubMed  Google Scholar 

  28. Watanabe-Ohnishi R, et al. Characterization of unique human TCR specifies for a family of streptococcal superantigens represented by rheumatogenic serotypes of M protein. J Immunol 1994: 152: 2026.

    Google Scholar 

  29. Guilherme L, et al. Human heart-infiltrating T-cell clones from rheumatic heart disease patients recognize both streptococcal and cardiac proteins. Circulation 1995: 92: 415.

    Article  PubMed  CAS  Google Scholar 

  30. Potocka-Plazak K, Noworolska A, Kocemba J Prevalence of autoantibodies in the very elderly association with symptoms ischemic heart disease. Aging Milano 1995: 7: 218.

    PubMed  CAS  Google Scholar 

  31. Maggi E, et al. Autoantibodies against oxidised low density lipoproteins in patients with coronary disease. Presse Med 1994: 9: 1158.

    Google Scholar 

  32. Alder Y, et al. The presence of antiphospholipid antibodies in acute myocardial infarction. Lupus 1995: 4: 309.

    Article  Google Scholar 

  33. Scheerder I, et al. Post cardiac injury syndrome and an increased humoral immune response against the major contractile proteins (actin and myosin). Am J Cardiol 1985: 56: 631.

    Article  PubMed  Google Scholar 

  34. Fu M, et al. Functional autoimmune epitode on al-adrenergic receptors in patients with malignant hypertension. Lancet 1994: 344: 1660.

    Article  PubMed  CAS  Google Scholar 

  35. Wallukat G, et al. The sera of spontaneously hypertensive rats contain agonistic auto-antibodies against the beta 1-adrenoceptor. J Hypertens 1995: 13: 1031.

    Article  PubMed  CAS  Google Scholar 

  36. Chiale P, et al. High prevalence of antibodies against betal-beta2 adrenoceptors in patients with primary electrical cardiac abnormalities. J Am Coll Cardiol 1995: 26: 864.

    Article  PubMed  CAS  Google Scholar 

  37. Frohn-Mulder I, et al. Clinical significance of maternal anti-Ro/SSA antibodies in children with isolated heart block. J Am Coll Card 1994: 23: 1677.

    Article  CAS  Google Scholar 

  38. Garcia S, et al. Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro/SSA positive patients in rabbit hearts. J Clin Invst 1994: 93: 718.

    Article  CAS  Google Scholar 

  39. Waltuck J, Buyon JP. Autoantibody-associated congenital heart block: outcome in mothers and children. Ann Intern Med 1994: 120: 544.

    PubMed  CAS  Google Scholar 

  40. Maisch B, et al. Value of immunohistological and immunoserological monitoring in cardiac transplantation. Eur Heart J 1987: 8(Suppl.J): 29.

    Article  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media New York

About this chapter

Cite this chapter

Konstadoulakis, M.M., Kymionis, G.D., Toutouza, M.G., Leandros, E. (1999). Autoimmune Cardiac Diseases. In: Contemporary Concepts in Cardiology. Developments in Cardiovascular Medicine, vol 217. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5007-5_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-5007-5_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7274-5

  • Online ISBN: 978-1-4615-5007-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics