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Hematopoietic Stem Cell Transplantation of Multiple Sclerosis, Rheumatoid Arthritis, and Systemic Lupus Erythematosus

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Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Part of the book series: Cancer Treatment and Research ((CTAR,volume 101))

Abstract

The standard treatment for autoimmune diseases is immune modulation or suppression. For patients with severe autoimmune diseases, some studies suggest a benefit of intensifying immunosuppression to the point of myelosuppression or myeloablation (1-12). In this setting reconstitution of a new hematopoietic and immune system is facilitated by infusion of hematopoietic progenitor cells (CD34+ cells) which expand and differentiate into T and B cells, macrophages, and monocytes.

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Authors and Affiliations

  1. Northwestern University Medical Center, Chicago, IL, 60611, USA

    Richard K. Burt M.D. & Ann Traynor M.D.

  2. Medical College of Wisconsin, Milwaukee, WI, 53226, USA

    William Burns M.D.

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    Richard K. Burt  & Mary M. Brush  & 

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Burt, R.K., Traynor, A., Burns, W. (1999). Hematopoietic Stem Cell Transplantation of Multiple Sclerosis, Rheumatoid Arthritis, and Systemic Lupus Erythematosus. In: Burt, R.K., Brush, M.M. (eds) Advances in Allogeneic Hematopoietic Stem Cell Transplantation. Cancer Treatment and Research, vol 101. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4987-1_8

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