Skip to main content
SpringerLink
Log in

Allogeneic Hematopoietic Stem Cell Transplantation in Recipients of Cellular or Solid Organ Allografts

  • Chapter
Book cover Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Part of the book series: Cancer Treatment and Research ((CTAR,volume 101))

Abstract

Transplantation of solid organs and cells (e.g., islets) has been made possible because of immunosuppressive agents. Cyclosporin A (CsA) or FK506 is often given in combination with other agents, such as polyclonal or monoclonal antibody based induction therapy, steroids, and/or mycophenolate mofetil (MMF). Immunosuppression must be administered throughout the recipient’s life, and while one year graft survival rates for solid organ transplants are excellent, the survival of transplanted organs drops dramatically over time (1). There are several adverse consequences associated with the use of chronic, generalized anti-rejection agents, including increased incidence of infection and malignancy, stunting of normal growth and development, diabetogenicity, nephrotoxicity, and osteoporosis (2-8).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Nagano H and Tilney NL. Chronic allograft failure: the clinical problem. The Amer J of the Med Sci 1997; 313(5): 305–309.

    Article  CAS  Google Scholar 

  2. Gaya SB, Rees AJ, Lechler RI, Williams G, Mason PD: Malignant disease in patients with long-term renal transplants. Transplantation 1995; 59(12): 1705–1709.

    Article  PubMed  CAS  Google Scholar 

  3. Balistreri WF, Bucuvalas JC, Ryckman FC: The effect of immunosuppression on growth and development. Liver Transl Surg 1995; l(suppl 5): 64–73.

    Google Scholar 

  4. Andoh TF, Burdmann EA, and Bennett WM: Nephrotoxicity of immunosuppressive drugs: experimental and clinical observations. Sem in Nephrol 1997; 17(1): 34–45.

    CAS  Google Scholar 

  5. Boudreaux JP, McHugh L, Canafax DM, Ascher N, Sutherland DE, Payne W, Simmons RL, Najarian JS, Fryd DS: The impact of cyclosporine and combination immunosuppression on the incidence of posttransplant diabetes in renal allograft recipients. Transplantation 1987; 44(3): 376–381.

    Article  PubMed  CAS  Google Scholar 

  6. Teuscher AU, Seaquist ER, Robertson DP: Diminished insulin secretory reserve in diabetic pancreas transplant and nondiabetic kidney transplant recipients. Diabetes 1994; 43(4): 593–598.

    Article  PubMed  CAS  Google Scholar 

  7. Christiansen E, Andersen HB, Rasmussen K, Christensen NJ, Olgaard K, Kirkegaard P, Tronier B, Volund A, Damsbo P, Burcharth F, et al: Pancreatic beta-cell function and glucose metabolism in human segmental pancreas and kidney transplantation.Am J Physiol 1993; 264(3): E441–E449.

    PubMed  CAS  Google Scholar 

  8. Schmaldienst S and Horl WH: Bacterial infections after renal transplantation. Nephron 1997; 75: 140–153.

    Article  PubMed  CAS  Google Scholar 

  9. Charlton B, Auchincloss Jr, H, Fathman CG: Mechanisms of transplantation tolerance. Ann Rev Immunol 1994; 12: 707–734.

    Article  CAS  Google Scholar 

  10. Kostecke RA, Ildstad ST: Chimerism and the facilitating cell. Transplant Rev 1995; 9: 97–110.

    Article  Google Scholar 

  11. Stewart FM, Crittenden RB, Lowry PA, Pearson-White S, Quesenberry PJ: Long-term engraftment of normal and post-5-fluorouracil murine marrow into normal nonmyeloablated mice. Blood 1993; 81: 2566–2571.

    PubMed  CAS  Google Scholar 

  12. Blumberg N, Heal JM: Effects of transfusion on immune function. Cancer recurrence and infection. Arch Pathol Lab Med 1994; 118: 371–379.

    PubMed  CAS  Google Scholar 

  13. Brennan DC, Mohanakumar T, Flye W: Donor-specific transfusion and donor bone marrow infusion in renal transplantation tolerance: a review of efficacy and mechanisms. Amer J of Kidney Dis 1995; 26(5): 701–715.

    Article  CAS  Google Scholar 

  14. Owen RD: Immunogenic consequences of vascular anastomosis between bovine twins. Science 1945; 102: 400–401.

    Article  PubMed  CAS  Google Scholar 

  15. Anderson D, Billingham RE, Lampkin GH, Medawar PB, Williams HLI: Heredity 1951;5: 379–397.

    Article  Google Scholar 

  16. Billingham RE, Brent L, Medawar P: Actively acquired tolerance of foreign cells. Nature 1953; 172: 603–606.

    Article  PubMed  CAS  Google Scholar 

  17. Kappler JW, Roehm N, Marrack P: T cell tolerance by clonal elimination in the thymus. Cell 1987; 49: 273–280.

    Article  PubMed  CAS  Google Scholar 

  18. Wood PJ, Streilein JW: Ontogeny of acquired immunological tolerance to H-2 alloantigens. Eur J Immunol 1982; 12: 188–194.

    Article  PubMed  CAS  Google Scholar 

  19. Cuttler AJ, Bell EB: Neonatally tolerant rats actively eliminate donor-specific lymphocytes despite persistent chimerism. Eur J Immunol 1996; 26: 320–328.

    Article  Google Scholar 

  20. Khan A, Tomita Y, Sykes M: Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Transplantation 1996; 62(3): 380–387.

    Article  PubMed  CAS  Google Scholar 

  21. Nikolic B, Lei H, Pearson DA, Sergio JJ, Swenson KG, Sykes M. Role of intrathymic rat class 11+ cells in maintaining deletional tolerance in xenogeneic rat → mouse bone marrow chimeras. Transplantation 1998; 65: 1216–1224.

    Article  PubMed  CAS  Google Scholar 

  22. Tutschka PJ, Ki PF, Beschorner WE, Hess AD, Santos GW. Suppressor cells in the transplantation tolerance. II. Maturation of suppressor cells in the bone marrow chimera. Transplantation 1981; 32: 321–325.

    Article  PubMed  CAS  Google Scholar 

  23. Roser BJ: Cellular mechanisms in neonatal and adult tolerance. Immunol Rev 1989; 107: 179–202.

    Article  PubMed  CAS  Google Scholar 

  24. Qin S, Cobbold SP, Benjamin R, Waldman H. Imduction of classical transplantation tolerance in the adult. J Exp Med 1990; 169: 779–794.

    Article  Google Scholar 

  25. Bemelman F, Honey K, Adams E, Cobbold S, Waldmann H. Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose. J Immunol 1998; 160: 2645–2648.

    PubMed  CAS  Google Scholar 

  26. Wood ML, Orosz CG, Gottschalk R, Monaco AP: The effect of injection of donor bone marrow on the frequency of donor-reactive CTL in antilymphocyte serum-treated, grafted mice. Transplantation 1992; 54: 665–671.

    Article  PubMed  CAS  Google Scholar 

  27. Martin P: Prevention of allogeneic marrow graft rejection by donor T cells that do not recognize recipient alloantigens: potential role of a veto mechanism. Blood 1996; 88(3): 962–969.

    PubMed  CAS  Google Scholar 

  28. Sambhara SR, Miller RG: Programmed cell death of T cells signaled by the T cell receptor and the a 3 domain of class I MHC: Science 1991; 252: 1424–1427.

    Article  PubMed  CAS  Google Scholar 

  29. Jankowski RA, Ildstad ST: Chimerism and tolerance: from freemartin cattle and neonatal mice to humans. Hum Immunol 1997; 52: 155–161.

    Article  PubMed  CAS  Google Scholar 

  30. Trentin JJ: Mortality and skin transplantability in X-irradiated mice receiving isologous, homologous or heterologous bone marrow. Proc Soc Exp Biol Med 1957; 92: 688–693.

    Google Scholar 

  31. Ildstad ST, Sachs DH: Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 1984; 307: 168–170.

    Article  PubMed  CAS  Google Scholar 

  32. Sharabi Y, Sachs DH: Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med 1989; 169: 493–502.

    Article  PubMed  CAS  Google Scholar 

  33. Singer A, Hathcock KS, Hodes RJ: Self recognition in allogeneic radiation bone marrow chimeras. A radiation-resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells. J Exp Med 1981; 153; 1286–1301.

    Article  PubMed  CAS  Google Scholar 

  34. Ildstad S, Wren S, Bluestone J, Barbieri S, Stephany D, Sachs D: Effect of selective T cell depletion of host and/or donor bone marrow on hemtopoietic repopulation, tolerance, and graft-vs-host disease in mixed allogeneic chimeras (B10 + B10.D2→ B10). J Immunol 1986, 136: 28–33.

    PubMed  CAS  Google Scholar 

  35. Ruedi E, Sykes M, Ildstad S, Chester C, Althage A, Hengartner H, Sachs S, Zinkernagel R: Antiviral T cell competence and restriction specificity of mixed aloogeneic (P1+ P2→ PI) irradiation chimeras. Cell Immunol 1989; 121: 185–195.

    Article  PubMed  CAS  Google Scholar 

  36. McCarthy SA, Griffith IJ, Gambel P, Francescutti LH, Wegman TG: Characterization of host lymphoid cells in antibody-facilitated bone marrow chimeras. Transplantation 1985; 40: 12–17.

    Article  PubMed  CAS  Google Scholar 

  37. Colson Y, Li H, Boggs SS, Patrene KD, Johnson PC, Ildstad ST: Durable mixed allogeneic chimerism and tolerance by a nonlethal radiation-based cytoreductive approach. J Immunol 1996; 157: 2820–2829.

    PubMed  CAS  Google Scholar 

  38. Ildstad ST, Wren SM, Boggs SS, Hronakes ML, Vecchini F, van den Brink MRM: Cross-species bone marrow transplantation: evidence for tolerance induction, stem cell engraftment, and maturation of T-lymphocytes in a xenogeneic stromal enviroment (rat (mouse). J Exp Med 1991; 174: 467–478.

    Article  PubMed  CAS  Google Scholar 

  39. Zeng YJ, Ricordi C, Tzakis A, Rilo HLR, Caroll PB, Starzl TE, Ildstad ST: Long term survival of donor-specific pancreatic islet xenografts in fully xenogeneic chimeras (WF rat → BIO mouse). Transplantation 1992; 53: 277–283.

    Article  PubMed  CAS  Google Scholar 

  40. Abou El-Ezz AY, Boggs SS, Johnson PC, Li H, Patrene KD, Istkowitz MS, Kaufman CL, Ildstad ST: A minimal conditioning approach to achieve stable multilineage mouse plus rat chimerism. Transplant Immunol 1995; 3: 98–106.

    Article  Google Scholar 

  41. Wong W, Morris, PJ, Wood K: Syngeneic bone marrow expressing a single donor class I MHC molecule permits acceptance of a fully allogeneic cardiac allograft. Transplantation 1996; 632(10): 1462–1468.

    Article  Google Scholar 

  42. Vallera DA, Blazar BR: T cell depletion for graft-versus-host disease prophylaxis. A perspective on engraftment in mice and humans. Transplantation 1989; 47: 751–760.

    Article  PubMed  CAS  Google Scholar 

  43. Sykes M, Eisenthal A, Sachs DH: Mechanism of protection from graft-vs.-host disease in murine mixed allogeneic chimeras: I. Development of a null cell population suppressive of CML responses and derived from the syngeneic bone marrow compartment. J Immunol 1988; 140: 2903–2911.

    PubMed  CAS  Google Scholar 

  44. Ildstad ST, Wren SM, Oh E, Hronakes ML: Mixed allogeneic reconstitution (A+B→A) to induce donor-specific transplantation tolerance: permanent acceptance of simultaneous skin grafts. Transplantation 1991; 51: 1262–1267.

    Article  PubMed  CAS  Google Scholar 

  45. Ildstad ST, Boggs SS, Vecchini F, Wren SM, Hronakes ML, Johnson PG, Van den Brink MRM: Mixed xenogeneic chimeras (rat + mouse → rat): evidence for rat stem cell engraftment, strain-specific transplantation tolerance, and skin-specific antigens. Transplantation 1992; 53: 815–822.

    Article  PubMed  CAS  Google Scholar 

  46. Slavin S, Strober S, Fuks Z, Kaplan HS: Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts. J Exp Med 1977;146: 34–48.

    Article  PubMed  CAS  Google Scholar 

  47. Zan-Bar I, Slavin S, Strober S: Induction and mechanism of tolerance to bovine serum albumin in mice given total lymphoid irradiation (TLI). J Immunol 1978;121: 1400–1404.

    PubMed  CAS  Google Scholar 

  48. Slavin S, Reitz B, Bieber CP, Kaplan HS, Strober S: Transplantation tolerance in adult rats using total lymphoid irradiation: permanent survival of skin, heart, and marrow allografts. J Exp Med 1978; 147: 700–707.

    Article  PubMed  CAS  Google Scholar 

  49. Prigozhina TB, Gurevitch O, Zhu J, Slavin S: Permanent and specific transplantation tolerance induced by a nonmyeloablative treatment to a wide variety of allontigeneic tissues. Transplantation 1997; 63: 1394–1399.

    Article  PubMed  CAS  Google Scholar 

  50. Colson YL, Wren SM, Schuchert MJ, Patrene KD, Johnson PC, Boggs SS, Ildstad ST: A nonlethal conditioning approach to achieve durable multilineage mixed chimerism and tolerance across major, minor, and hematopoietic histocompatibility barriers. J Immunol 1995; 155: 4179–4188.

    PubMed  CAS  Google Scholar 

  51. Bryson JS, Jennings CD, Caywood BE, Kaplan AM: Induction of a syngeneic graft-versus-host disease-like syndrome in DBA/2 mice. Transplantation 1989; 48: 1042–1047.

    Article  PubMed  CAS  Google Scholar 

  52. Bryson JS, Caywood BE, Kaplan AM: Relationship of cyclosporine A-mediated inhibition of clonal deletion and development of syngeneic graft-versus-host disease. J Immunol 1991; 147: 391–397.

    PubMed  CAS  Google Scholar 

  53. Woo J, Ildstad ST, Thompson AW: FK 506 inhibits the differentiation of developing thymocytes but not negative selection of T cell receptor Vβ5+ and Vβ 1+ T lymphocytes in vivo. Transplant Immunol 1994; 2: 11–21.

    Article  CAS  Google Scholar 

  54. Woo J, Thomson AW, Ildstad ST: Effects of FK 506 on chimerism and the induction of donor-specific unresponsiveness following fully allogeneic bone marrow transplantation in mice. Transplant Immunol 1995; 3: 86–90.

    Article  CAS  Google Scholar 

  55. Murace N, Starzl TE, Tanabe M, Fujisaki S, Miyazawa H, Ye Q, Delaney CP, Fung JJ, Demetris AJ: Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to Brown Norway rats. Transplantation 1995; 60: 158–171.

    Google Scholar 

  56. Monaco AP, Wood ML, Russel PS: Studies on heterologous antilymphocyte serum in mice. III. Immunologic tolerance and chimerism produced across the H-2 locus with adult thymectomy and anti-lymphocyte serum. Ann NY Acad Sci 1966; 129: 190–206.

    Article  Google Scholar 

  57. Monaco AP, Wood ML: Studies on heterologous antilymphocyte serum in mice. VII. Optimal cellular antigen for induction of immunologic tolerance with antilymphocyte serum. Transplant Proc 1970; 2: 489–496.

    PubMed  CAS  Google Scholar 

  58. Wood ML, Monaco AP, Gozzo JJ, Liegeois A: Use of homozygous allogeneic bone marrow for induction of tolerance with antilymphocyte serum: dose and timing. Transplant Proc 1971;3: 676–679.

    PubMed  CAS  Google Scholar 

  59. Wood ML, Monaco AP: The effect of timing of skin grafts on subsequent survival in ALS-treated, marrow-infused mice. Transplantation 1977; 23: 78–86.

    Article  PubMed  CAS  Google Scholar 

  60. Sharabi Y, Aksentijevich I, Sundt TM III, Sachs DH, Sykes M: Specific tolerance induction across a xenogeneic barrier: production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen. J Exp Med 1990; 172: 195–202.

    Article  PubMed  CAS  Google Scholar 

  61. de Vries-van der Zwan A, Besseling C, de Waal LP, Boog CJ: Specific tolerance induction and transplantation: a single-day protocol. Blood 1997; 89: 2596–2601.

    Google Scholar 

  62. George JF, Sweeney SD, Kirklin JK, Simpson EM, Goldstein DR, Thomas JM: An essential role for Fas ligand in transplantation tolerance induced by donor bone marrow. Nat Med 1998; 4: 333–335.

    Article  PubMed  CAS  Google Scholar 

  63. Pearson TC, Alexander DZ, Hendrix R, Elwood ET, Lisnley PS, Winn KJ, Larsen CP: CTLA4-Ig plus bone marrow induces long term allograft survival and donor specific unresponsiveness in the murine model. Transplantation 1996; 61; 997–1004.

    Article  PubMed  CAS  Google Scholar 

  64. Lin H, Boiling SF, Linsley PS, Wei RQ, Gordon D, Thompson CB, Turka LA: Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4-Ig plus donor specific transfusion. J Exp Med1993; 178: 1801–1806.

    Article  PubMed  CAS  Google Scholar 

  65. Orloff MS, DeMara EM, Coppage ML, Leong N, Fallon MA, Sickel J, Zuo XJ, Prehn J, Jordan SC: Prevention of chronic rejection and graft arteriosclerosis by tolerance induction. Transplantation 1995; 59: 282–288.

    PubMed  CAS  Google Scholar 

  66. Blom D, Morrissey N, Mesonero C, Zuo XJ, Jordan S, Fisher T, Bronsther O, Orloff MS: Tolerance induction by intrathymic inoculation presents chronic renal allograft rejection. Transplantation 1998; 65: 272–275.

    Article  PubMed  CAS  Google Scholar 

  67. LaFace DW, Peck AB: Reciprocal allogeneic bone marrow transplantation between NOD mice and diabetes-nonsusceptible mice associated with transfer and prevention of autoimmune diabetes. Diabetes 1989; 38: 894.

    Article  PubMed  CAS  Google Scholar 

  68. Li H, Kaufman CL, Boggs SS, Johnson PC, Patrene KD, Ildstad ST: Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice. J Immunol 1996; 156(1): 380–388.

    PubMed  CAS  Google Scholar 

  69. Mathieu C, Casteels K, Bouillon R, Waer M: Protection against autoimmune diabetes in mixed bone chimeras. J Immunol 1997; 158: 1453–1457.

    PubMed  CAS  Google Scholar 

  70. Storb R, Raff RF, Appelbaum FR, Deeg HJ, Graham TC, Schuening FG, Sale G, Bryant E, Seidel K: Fractionated versus-dose total body irradiation at low and high dose rates to condition canine littermates for DLA-Identical marrow grafts. Blood 1994; 83(11): 3384–3389.

    PubMed  CAS  Google Scholar 

  71. Storb R, Raff RF, Deeg HJ, Graham TC, Schuening FG, Shulman H, Bryant E: DLA-Identical marrow grafts after low-dose total-body irradiation. Transplantation 1995; 59(10): 1481–1502.

    Article  PubMed  CAS  Google Scholar 

  72. Storb R, Raff R, Deeg HJ, Graham T, Appelbaum FR, Scheuning FG, Shulman H, Seidel K, Leisenring W: Dose rate-dependent sparing of the gastrointestinal tract by fractionated total body irradiation in dogs given marrow autografts. Physics 1998; 40(4): 961–966.

    Google Scholar 

  73. Yu C, Storb R, Deeg HJ, Graham TC, Scheuning FG, Huss R, Seidel K, Fitzsimmons WE: Tacrolimus (FK506) and methotrexate regimens to prevent graft-versus-host disease after unrelated dog leukocyte antigen (DLA) nonidentical marrow transplantation. Bone Marrow Transplantation 1996; 17(4): 649–653.

    PubMed  CAS  Google Scholar 

  74. Storb R, Yu C, Wagner JL, Deeg HJ, Nash RA, Kiem HP, Leisenring W, Shulman H: Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation. Blood 1997; 89(8): 3048–3054.

    PubMed  CAS  Google Scholar 

  75. Yu C, Seidel K, Nash RA, Deeg HJ, Sandmaier BM, Barsoukov A, Santos E, Storb R: Synergism between mycophenolate mofetil and cyclosporine in preventing graft-versus-host disease among lethally irradiated dogs given DLA-nonidentical unrelated marrow grafts. Blood 1998; 91(7): 2581–2587.

    PubMed  CAS  Google Scholar 

  76. Berenson RJ, Bensinger WI, Kalamasz D, Schuening F, Deeg HJ, Graham T, Storb R: Engraftment of dogs with la-positive marrow cells isolated by Avidin-Biotin immunoadsorption. Blood 1987; 69(5): 1363–1367.

    PubMed  CAS  Google Scholar 

  77. Storb R, Epstein RB, Ragde H, Thomas ED: Marrow grafts by combined marrow and leukocyte infusions in unrelated dogs selected by histocompatibility typing. Transplantation 1979; 6: 587–593.

    Article  Google Scholar 

  78. Deeg HJ, Storb R, Weiden PL, et al: Abrogation of resistance to and enhancement in DLA-nonidentical unrelated marrow grafts in lethally irradiated dogs by thoracic duct lymphocytes. Blood 1979; 53: 552–557.

    PubMed  CAS  Google Scholar 

  79. Storb R, Deeg HJ: Failure of allogeneic canine marrow grafts after total body irradiation. Allogeneic’ resistance’ versus transfusion-induced sensitization. Transplantation 1986; 42: 571–580.

    Article  PubMed  CAS  Google Scholar 

  80. Schwarzinger I, Raff RF, Flowers M, Niederwieser D, Graham T, Shulman H, Appelbaum FR, Scheuning F, Storb R: Recipient-specific donor cytotoxic T lymphocytes enhance engraftment of unrelated, DLA non-identical canine marrow. Bone Marrow Transplantation 1994; 13: 303–309.

    PubMed  CAS  Google Scholar 

  81. De Revel T, Appelbaum FR, Storb R, Scheuning F, Nash R, Deeg HJ, McNiece I, Andrews RO Graham T: Effects of granulocyte colony-stimulating factor and stem cell factor, alone and in combination, on the mobilization of peripheral blood cells that engraft lethally irradiated dogs. Blood 1994; 83(12): 3795–3799.

    PubMed  Google Scholar 

  82. Storb R, Raff RF, Appelbaum FR, Deeg HJ, Graham T, Scheuning FG, Shulman H, Yu C, Bryant E, Burnett R, Seidel K: DLA-identical bone marrow grafts after low-dose total body irradiation: The effect of canine recombinant hematopoietic growth factors. Blood 1994; 84(10): 3558–3566.

    PubMed  CAS  Google Scholar 

  83. Sandmaier BM, Storb R, Bennett KL, Appelbaum FR, Santos EB: Epitope specificity of CD44 for monoclonal antibody-dependent facilitation of marrow engraftment in a canine model. Blood 1998; 91(9): 3494–3502.

    PubMed  CAS  Google Scholar 

  84. Caridis T, Liegeois A, Barrett I, Monaco AP: Enhanced survival of canine real allografts of ALS-treated dogs given bone marrow. Transplantation Proc 1973; 5: 671–673.

    CAS  Google Scholar 

  85. Hartner WC, De Fazio SR, Maki T, Markees TG, Monaco AP, Gozzo JJ: Prolongation of renal allograft survival in antilymphocyte serum-treated dogs by postoperative injection of density-gradient-fractionated donor bone marrow.Transplantation 1986; 42: 593–597.

    Article  PubMed  CAS  Google Scholar 

  86. Hartner WC, De Fazio SR, Markees TG, Maki T, Monaco AP, Gozzo JJ: Specific tolerance to canine renal allografts following treatment with fractionated bone marrow and antilymphocyte serum. Transplantation Proc 1987;19: 476–477.

    CAS  Google Scholar 

  87. Hartner WC, De Fazio SR, Markees TG, Khouri WA, Maki T, Monaco AP, Gozzo JJ: Effect of cyclosporin A supplementation and on renal allograft survival in ALS plus bone marrow treated dogs. Transplantation Proc 1989;21(1): 959–960.

    CAS  Google Scholar 

  88. Hartner WC, Markees TC, De Fazio SR, et al: the effect of antilymphocyte serum, fractionated donor bone marrow, and cyclosporine on renal allograft survival in mongrel dogs. Transplantation 1991; 52: 784–789.

    Article  PubMed  CAS  Google Scholar 

  89. Hartner WC, Shaffer D, Markees TG, De Fazio SR, Monaco AP, Gozzo JJ: Effect of cyclosporine A treatment on induction of donor specific unresponsiveness in mongrel dogs following a short course of ALS and donor bone marrow infusion. Transplantation Proc 1991; 23: 477–479.

    CAS  Google Scholar 

  90. Hartner WC, Markees TG, De Fazio SR, Shaffer D, Van derWerf WJ, Gilchrist B, Yatko C, Monaco AP, Gozzo JJ: Effect of early administration of donor bone marrow cells on renal allograft survival in dogs treated with antilymphocyte serum and cyclosporine. Transplantation 1995; 59(1): 131–154.

    Article  PubMed  CAS  Google Scholar 

  91. Mathews KA, Holmberg DL, Johnston K, Miller CM, Binnington AG, Maxie G, Atilola M, Smith G: Renal allograft survival in outbred mongrel dogs using rabbit anti-dog thymocyte serum in combination with immunosuppressive drug therapy with or without donor bone marrow. Veterinary Surgery 1994; 23: 347–357.

    Article  PubMed  CAS  Google Scholar 

  92. Hartner WC, Van der Werf WJ, Lodge JP, Gilchrist B, De Fazio SR, Markees TG, Yatko C, Monaco AP, Gozzo JJ: Effect of rapamycin on renal allograft survival in canine recipients treated with antilymphocyte serum, donor bone marrow, and cyclosporine. Transplantation 1995; 60(11): 1347–1350.

    PubMed  CAS  Google Scholar 

  93. Yamamoto M: Prolongation of canine renal allograft survival in combined therapy with rabbit-anti-dog antilymphocytic serum, azathioprine and the allotransplantation of the donor’s bone marrow. Tohoku J. Exp Med. 1970; 101: 333–338.

    Article  PubMed  CAS  Google Scholar 

  94. Kenyon NS, Selvaggi G, Fernandez L, Xu XM, Knapp J, Montelongo J, McMannis J, Russel TR, Alejandro R, Ricordi: Infusion of class II DIM donor bone marrow enhances islet allograft survival in low-dose CyA treated dogs. Transplantation Proc 1997; 29(4): 2189.

    Article  CAS  Google Scholar 

  95. Brendel MD, Kong SS, Schachner RD, Qian T, Selvaggi G, Alejandro R, Mintz DH, Ricordi C, Federlin K, Bretzel RG: The influence of donor specific vertebral body derived bone marrow cell infusion on canine islet allograft survival without irradiation conditioning of the recipient. Exp & Clin Endocrine & Diabetes 1995; 103(2): 129–132.

    Article  Google Scholar 

  96. Brendel MD, Kong SS, Schachner RD, Qian T, Selvaggi G, Alejandro R, Mintz DH, Ricordi C: Canine islet allograft survival after donor specific vertebral body derived bone marrow cell transplantation without irradiation conditioning of the recipient. Transplantation Proc 1995; 27(6): 3174.

    CAS  Google Scholar 

  97. Schumm M, Gunther W, Kolb HJ, Rieber P, Buttner M, Voss C, Kremmer E, Reitmeier P, Thierfelder S, Wilmanns W: Prevention of graft-versus-host disease in DLA-haplotype mismatched dogs and hemopoietic engraftment of CD6-depleted marrow with and without cG-CSF treatment after transplantation. Tissue Antigens 1994;43: 170–178.

    Article  PubMed  CAS  Google Scholar 

  98. Kolb HJ, Gunther W, Schumm M, Holler E, Wilmanns W, Thierfelder S: Adoptive immunotherapy in canine chimeras. Transplantation 1997; 63(3): 430–436.

    Article  PubMed  CAS  Google Scholar 

  99. Wagemaker G, Vriesendorp HM, and van Bekkum DW: Successful bone marrow transplantation across major histocompatibility barriers in Rhesus monkeys. Transplantation Proc 1981; 13(1): 875–880.

    CAS  Google Scholar 

  100. Thomas FT, Carver FM, Foil MB, Pryor WH, Larkin EW, Hall WR, Haisch CE, Thomas JM: Long-term incompatible kidney survival in outbred higher primates without chronic immunosuppression. Ann. Surg 1983; 370–378.

    Google Scholar 

  101. Thomas J, Carver M, Cunningham P, Park K, Gonder J, Thomas F: Promotion of incompatible allograft acceptance in rhesus monkeys given posttransplant antithymocyte globulin and donor bone marrow: Transplantation 1987; 43(3): 332–338.

    Article  PubMed  CAS  Google Scholar 

  102. Thomas JM, Carver FM, Foil MB, Hall WR, Adams C, Fahrenbruch GB, Thomas FT: Renal allograft tolerance induced with ATG and donor bone marrow in outbred rhesus monkeys. Transplantation 1993;36(1): 104–106..

    Google Scholar 

  103. Thomas JM, Carver M, Cunningham P, Sash C, Park K, Thomas F: Promotion of incompatible allograft acceptance in rhesus monkeys given posttransplant antithymocyte globulin and donor bone marrow II. Effects of adjuvant immunosuppressive drugs. Transplantation 1989;47: 209–215..

    Article  PubMed  CAS  Google Scholar 

  104. Moses RD, Orr DS, Bacher JD, Sachs DH, Clark RE, Gress RE: Cardiac allograft survival across major histocompatibility complex barriers in the rhesus monkey following T Lymphocyte-depleted autologous marrow transplantation. II.Prolonged allograft survival with extensive marrow T cell depletion. Transplantation 1989; 47(3): 435–444.

    Article  PubMed  CAS  Google Scholar 

  105. Moses RD, Sharrow SO, Stephany DA, Orr KS, Gress RE: Cardiac allograft survival across major histocompatibility complex barriers in the rhesus monkey following T Lymphocyte-depleted autologous marrow transplantation. Transplantation 1989;48: 774–781.

    Article  PubMed  CAS  Google Scholar 

  106. Thomas JM, Carver FM, Kasten-Jolly J, Haisch CE, Rebellato LM, Gross U, Vore SJ, Thomas FT: Further studies of veto activity in rhesus monkey bone marrow in relation to allograft tolerance and chimerism. Transplantation 1994; 57: 101–115.

    Article  PubMed  CAS  Google Scholar 

  107. Thomas JM, Verbanac KM, Smith JP, Kasten-Jolly J, Gross U, Reballato LM, Haisch CE, Carver FM, Thomas FT: The facilitating effect of one-DR antigen sharing in renal allograft tolerance induced by donor bone marrow in rhesus monkeys: Transplantation 1995; 59: 245–255.

    PubMed  CAS  Google Scholar 

  108. Thomas JM, Neville DM, Contreras JL, Eckhoff DE, Meng G, Lobashevsky AL, Wang PX, Huang ZQ, Verbanac KM, Haisch CE, Thomas FT: Preclinical studies of allograft tolerance in rhesus monkeys. Transplantation 1997; 64: 124–135.

    Article  PubMed  CAS  Google Scholar 

  109. Monaco AP, Clark AW, Wood ML, Sahyoun AI, Codish SD, Brown RW: Possible active enhancement of a human cadaver renal allograft with antilymphocyte serum (ALS) and donor bone marrow: case report of an initial attempt. Surgery 1976; 79(4): 384–392.

    PubMed  CAS  Google Scholar 

  110. Barber WH, Mankin JA, Laskow DA, Deierhoi MH, Julian BA, Curtis JJ, Diethelm AG: Long-term results of a controlled prospective study with transfusion of donor-specific bone marrow in 57 cadaveric renal allograft recipients. Transplantation 1991; 51(1): 70–75.

    Article  PubMed  CAS  Google Scholar 

  111. McDaniel DO, Naftilan J, Hulvey K, Shaneyfelt S, Lemons JA, Logoo-Deenadayalan S, Hudson S, Diethelm AG, Barber WH: Peripheral blood chimerism in renal allograft recipients transfused with donor bone marrow. Transplantation 1994; 57(6): 852–856.

    Article  PubMed  CAS  Google Scholar 

  112. Starzl TE, Demetris AJ, Noriko M, Ildstad ST, Ricordi C, Trucco M: Cell migration, chimerism and graft acceptance. Lancet 1992; 339: 1579–2582.

    Article  PubMed  CAS  Google Scholar 

  113. Starzl TE, Demetris AJ, Trucco M, Ricordi C, Murase N, Thomson AW: The role of cell migration and chimerism in organ transplant acceptance and tolerance induction. Transplant Science 1993; 3: 47–50.

    Google Scholar 

  114. Fontes P, Rao A, Demetris AJ, Zeevi A, Trucco M, Carroll P, Rybka W, Ricordi C, Dodson F, Shapiro R, Tzakis AG, Todo S, Abu-Elmagd K, Jordan M, Fung JJ, Starzl TE: Bone marrow augmentation of donor-cell chimerism in kidney, liver, heart, and pancreas islet transplantation. Lancet 1994; 344(8916): 151–155.

    Article  PubMed  CAS  Google Scholar 

  115. Zeevi A, Pavlick M, Lombardozzi S, Banas R, Pappo O, Rao AS, Fontes P, Demetris J, Shapiro R, Forrest D, Trucco M, Carroll P, Pham S, Fung JJ, Strazl TE: Immune status of recipients following bone marrow-augmented solid organ transplantation. Transplantation 1995; 59(4): 616–620.

    PubMed  CAS  Google Scholar 

  116. Zeevi A, Pavlick M, Banas R, Bentlejewski C, Spichty K, Rao AS, Fontes A, Lyengar A, Shapiro R, Dodson F, Jordan M, Pham S, Keenan R, Griffith B, Corry R, Egidi F, Fung JJ, Starzl TE: Three years of follow-up of bone marrow-augmented organ transplant recipients: The impact of donor-specific immune modulation. Transplant Proc 1997; 29: 1205–1206.

    Article  PubMed  CAS  Google Scholar 

  117. Gaetano C, Garcia-Morales R, Burke GW, Roth D, Esquenazi V, Tzakis AG, Miller J: Donor bone marrow, chimerism, histocompatibility and renal allograft rejection. Transplant Proc 1998: in press.

    Google Scholar 

  118. Tsaroucha A, Ricordi C, Noto TA, Kenyon NS, Garcia-Morales R, Nery J, Miller J, and Tzakis A: Donor peripheral stem cell infusion in recipients of living related liver allografts. Transplantation 1997; 64(2): 362–364.

    Article  PubMed  CAS  Google Scholar 

  119. Ricordi C, Karatzas T, Selvaggi G, Nery J, Webb M, Fernandez H, Ruiz P, Kong SS, Esquenazi V, Miller J, Schiff E, Tzakis AG: Multiple bone marrow infusions to enhance acceptance of allografts from the same donor. AnnN Y Acad Sci 1995; 70: 345–350.

    Article  Google Scholar 

  120. Ricordi C, Karatzas T, Nery J, Webb M, Selvaggi G, Fernandez L, Khan FA, Ruiz P, Schiff E, Olson L, Fernandez H, Bean J, Esquenazi V, Miller J, Tzakis AG: High dose donor bone marrow infusions to enhance allograft survival: The effect of timing.Transplantation 1997; 63: 7–11.

    Article  PubMed  CAS  Google Scholar 

  121. Garcia-Morales R, Esquenazi V, Zucker K, Gomez C, Fuller L, Carreno M, Cirocco R, Alamo A, Karatzas T, Burke II GW, Ciancio G, Temple D, Fernandez H, Ricordi C, Tzakis AG, Miller J: An assessment of the effects of cadaver donor bone marrow on kidney allograft recipient blood cell chimerism by a novel technique combining PCR and flow cytometry (PCR-Flow). Transplantation 1996; 62: 1149–1160.

    Article  PubMed  CAS  Google Scholar 

  122. Garcia-Morales R, Carreno M, Mathew J, Cirocco R, Zucker K, Ciancio G, Burke G, Roth D, Temple D, Fuller L, Esquenazi V, Eskind L, Kenyon NS, Ricordi C, Tzakis AG, Miller J: Continuing observations on the regulatory effects of donor-specific bone marrow cell infusions and chimerism in kidney transplant recipients. Transplantation 1998; 5(7): 956–965.

    Article  Google Scholar 

  123. McDaniel ML, Kwon G, Hill JR, Marshall CA, Corbett J: Cytokines and nitric oxide in islet inflammation and diabetes. Proc Soc Exp Biol Med 1996; 211(1): 24–32.

    PubMed  CAS  Google Scholar 

  124. Kenyon NS, Selvaggi G, Fernandez L, Xiu XM, Knapp J, Montelongo J, McMannis J, Russell TR, Alejandro R, and Ricordi C: Infusion of class II dim donor bone marrow enhances islet allograft survival in low dose CsA treated dogs. Txpl Proc 1997; 29: 2189.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Diabetes Research Institute Departments of Medicine and Surgery, University of Miami School of Medicine and Miami VA Medical Center, Miami, FL, USA

    Norma S. Kenyon, Maria Chatzipetrou, Andreas Tzakis, Joshua Miller, Rodolfo Alejandro & Camillo Ricordi

Authors
  1. Norma S. Kenyon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maria Chatzipetrou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Andreas Tzakis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Joshua Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rodolfo Alejandro
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Camillo Ricordi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Northwestern University Medical Center, Chicago, USA

    Richard K. Burt  & Mary M. Brush  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media New York

About this chapter

Cite this chapter

Kenyon, N.S., Chatzipetrou, M., Tzakis, A., Miller, J., Alejandro, R., Ricordi, C. (1999). Allogeneic Hematopoietic Stem Cell Transplantation in Recipients of Cellular or Solid Organ Allografts. In: Burt, R.K., Brush, M.M. (eds) Advances in Allogeneic Hematopoietic Stem Cell Transplantation. Cancer Treatment and Research, vol 101. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4987-1_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-4987-1_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7264-6

  • Online ISBN: 978-1-4615-4987-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation