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Thyroid Cancer pp 105–137Cite as

Pathologic Features of Thyroid Tumors

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Part of the book series: Endocrine Updates ((ENDO,volume 2))

Abstract

Thyroid tumors include those arising from follicular epithelium, C cells, mesenchymal elements and lymphoid cells. The majority of thyroid neoplasms derive from follicular cells. The classification and understanding of thyroid neoplasms has evolved during the last century from a relatively simple model (1) to one more complex and clinically helpful. The most widely used and accepted classifications are those issued by the World Health Organization (WHO) and the Armed Forces Institute of Pathology (AFIP). The Armed Forces Institute of Pathology issued the series one fascicle of thyroid tumors in 1953 (2) and the WHO published its first histologic classification of thyroid tumors in 1974 (3). Since then, the second edition of the WHO publication appeared in 1988 (4) and the third series of the AFIP fascicle series in 1992 (5).

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References

  1. Osier W. The Principles and Practice of Medicine. New York: Appelton & Co., 1892.

    Google Scholar 

  2. Warren S, Meissner WA. Tumors of the Thyroid Gland. Washington: Armed Forces Institute of Pathology, 1993.

    Google Scholar 

  3. Hedinger CE, Sobin LH. Histologic typing of Thyroid Tumors, Geneva: World Health Organization, 1974.

    Google Scholar 

  4. Hedinger CE. Histologic Typing of Thyroid Tumors, 2nd ed. Berlin:Springer-Verlag, 1988.

    Google Scholar 

  5. Rosai J, Carcangiu ML, DeLellis RA. Tumors of the Thyroid Gland. Washington: Armed Forces Institute of Pathology, 1992.

    Google Scholar 

  6. LiVolsi VA. Surgical Pathology of the Thyroid. Philadelphia: W. B. Saunders, 1990.

    Google Scholar 

  7. Johannessen JV, Sobrinho-Simoes M. The origin and significance of thyroid psammoma bodies. Lab Invest 1980;43:287–296.

    PubMed  CAS  Google Scholar 

  8. Patchefsky AS, Hoch WS. Psammoma bodies in diffuse toxic goiter. Am J Clin Pathol 1972;57:551–556.

    PubMed  CAS  Google Scholar 

  9. Dugan JM, Atkinson BF, Avitabile A, Schimmel M, LiVolsi VA. Psammoma bodies in fine needle aspirate of the thyroid in lymphocytic thyroiditis. Acta Cytol 1987;31:330–334.

    PubMed  CAS  Google Scholar 

  10. Lee T-K, Myers RT, Marshall RB, Bond MG, Kardon B. The significance of mitotic rate: a retrospective study of 127 thyroid carcinomas. Hum Pathol 1985;16:1042–1046.

    PubMed  CAS  Google Scholar 

  11. Carcangiu ML, Zampi G, Pupi A, Castagnoli A, Rosai J. Papillary carcinoma of the thyroid. A clinicopathologic study of 241 cases treated at the University of Florence, Italy. Cancer 1985;55:805–828.

    PubMed  CAS  Google Scholar 

  12. Franssila KO. Is the differentiation between papillary and follicular thyroid carcinoma valid? Cancer 1973;32:853–864.

    PubMed  CAS  Google Scholar 

  13. Raphael SJ, McKeown-Eyssen G, Asa SL. High-molecular-weight cytokeratin and cytokeratin-19 in the diagnosis of thyroid tumors. Mod Pathol 1994;7:295–300.

    PubMed  CAS  Google Scholar 

  14. Schelfhout LJDM, Van Muijen GNP, Fleuren GJ. Expression of keratin 19 distinguishes papillary thyroid carcinoma from follicular carcinoma and follicular thyroid adenoma. Am J Clin Pathol 1989;92:654–658.

    PubMed  CAS  Google Scholar 

  15. Figge J, del Rosario AD, Gerasimov G, Dedov I, Bronstein M, Troshina K, Alexandrova G, Kallakury B, Bui HX, Bratslaysky G, Ross JS. Preferential expression of the cell adhesion molecule CD44 in papillary thyroid carcinoma. Exp Mol Pathol 1994;61:203–211.

    PubMed  CAS  Google Scholar 

  16. Chhieng DC, Ross JS, Mckenna BJ. CD44 immunostaining of thyroid fine-needle aspirates differentiates thyroid papillary carcinoma from other lesions with nuclear grooves and inclusions. Cancer 1997;81:157–162.

    PubMed  CAS  Google Scholar 

  17. Ott RA, McCall AR, McHenry C, Jarosz H, Armin A, Lawrence AM, Paloyan E. The incidence of thyroid carcinoma in Hashimoto’s thyroiditis. Am Surg 1987;53:442–445.

    PubMed  CAS  Google Scholar 

  18. McConahey WM, Hay ID, Woolner LB, van Heerden JA, Taylor WF. Papillary thyroid cancer treated at the Mayo Clinic, 1946 through 1970: initial manifestations, pathologic findings, therapy and outcome. Mayo Clin Proc 1986;61:978–996.

    PubMed  CAS  Google Scholar 

  19. Christensen SB, Ljungberg O, Tibblin S. Thyroid carcinoma in Malmo, 1960–1977: epidemiologic, clinical and prognostic findings in a defined urban population. Cancer 1984;53:1625–1633.

    PubMed  CAS  Google Scholar 

  20. Howard RB, Truels WP. Thyroid cancer: 30 year review of 201 cases. Am J Surg 1979;138:934–938.

    PubMed  CAS  Google Scholar 

  21. Schindler A-M, van Melle G, Evequoz B, Scazziga B. Prognostic factors in papillary carcinoma of the thyroid. Cancer 1991;68:324–330.

    PubMed  CAS  Google Scholar 

  22. Tscholl-Ducommun J, Hedinger CE. Papillary thyroid carcinomas. Morphology and prognosis. Virchows Arch (A) 1982;396:19–39.

    CAS  Google Scholar 

  23. Lindsay S. Carcinoma of the thyroid gland. A clinical and pathologic study of 293 patients at the University of California Hospital. Springfield, IL. Charles C Thomas, 1960.

    Google Scholar 

  24. Chen KT, Rosai J. Follicular variant of thyroid papillary carcinoma: a clinicopathologic study of six cases. Am J Surg Pathol 1977;1:123–130

    Google Scholar 

  25. Rosai J, Zampi G, Carcangiu ML. Papillary carcinoma of the thyroid: a discussion of its several morphologic expressions with particular emphasis on the follicular variant. Am J Surg Pathol 1983;7:809–817.

    PubMed  CAS  Google Scholar 

  26. Hawk WA, Hazard JB. The many appearances of papillary carcinoma of the thyroid. Cleveland Clin Quart 1976;43:207–216.

    PubMed  CAS  Google Scholar 

  27. Schröder S, Böcker W, Dralle H, Kortman K-B, Stern C. The encapsulated papillary carcinoma of the thyroid. A morphologic subtype of the papillary thyroid carcinoma. Cancer 1984;54:90–93.

    PubMed  Google Scholar 

  28. Evans HL. Encapsulated papillary neoplasms of the thyroid. A study of 14 cases followed for a minimum of 10 years. Am J Surg Pathol 1987;11:592–597.

    PubMed  CAS  Google Scholar 

  29. Carcangiu ML, Bianchi S. Diffuse sclerosing variant of papillary thyroid carcinoma. Clinicopathologic study of 15 cases. Am J Surg Pathol 1989;13:1041–1049.

    PubMed  CAS  Google Scholar 

  30. Soares J, Limbert E, Sobrinho-Simöes M. Diffuse sclerosing variant of papillary thyroid carcinoma. A clinicopathologic study of 10 cases. Pathol Res Pract 1989;185:200–206.

    PubMed  CAS  Google Scholar 

  31. Fujimoto Y, Obara T, Ito Y, Kodama T, Aiba M, Yamaguchi K. Diffuse sclerosing variant of papillary carcinoma of the thyroid. Cancer 1990;66:2306–2312.

    PubMed  CAS  Google Scholar 

  32. Harach HR, Williams GT, Williams ED. Familial adenomatous polyposis thyroid carcinoma: a distinct type of follicular cell neoplasm. Histopathology 1994;25:549–561. ’

    PubMed  CAS  Google Scholar 

  33. Peters SB, Chatten I, LiVolsi VA. Pediatric papillary thyroid carcinoma. Modem Pathol 1994;7: 55A.

    Google Scholar 

  34. Heffess C, Adair C, Thompson L, Wenig B. Morphologic patterns and clinicopathologic features of papillary thyroid carcinoma in children. Modern Pathol 1995;8:53A.

    Google Scholar 

  35. Mizukami Y, Noguchi M, Michigishi T, Nonomura A, Hashimoto T, Otake S, Nakamura S, Matsubara F. Papillary thyroid carcinoma in Kanazawa, Japan: prognostic significance of histological subtypes. Histopathology 1992;20:243–250.

    PubMed  CAS  Google Scholar 

  36. Nikiforov YE, Gnepp DR. Pediatric thyroid cancer after the Chemobyl disaster: Pathomorphologic study of 84 cases (1991–1992) from the Republic of Belarus. Cancer 1994;74:748–766.

    PubMed  CAS  Google Scholar 

  37. Bogdanova T, Bragarnik M, Tronko ND, Harach HR, Thomas GA, Williams ED: Thyroid cancer in the Ukraine post Chernobyl. Thyroid 1995;5,Suppl 1:S-28.

    Google Scholar 

  38. Nikiforov YE, Rowland JM, Bove KE, Monforte-Munoz H, Fagin JA. Distinct pattern of ret oncogene rearrangements in morphologic variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Research 1997;57:1690–1694.

    PubMed  CAS  Google Scholar 

  39. Nikiforov YE, Fagin JA, Biddinger P. Association of different ret/PTC rearrangements with behavior and morphology of pediatric papillary carcinoma. Modern Pathol 1998;11:58A.

    Google Scholar 

  40. Ostrowski ML, Merino MJ. Tall cell variant of papillary thyroid carcinoma. A reassessment and immunohistochemical study with comparison to the usual type of papillary carcinoma of the thyroid. Am J Surg Pathol 1996;20:964–974.

    PubMed  CAS  Google Scholar 

  41. Wenig BM, Heffess CS, Adair CF. Atlas of Endocrine Pathology. Philadelphia: W. B. Saunders, 1997.

    Google Scholar 

  42. Johnson TL, Lloyd RV, Thompson NW, Beierwaltes WH, Sisson JC. Prognostic implications of the tall cell variant of papillary thyroid carcinoma. Am J Surg Pathol 1988;12:22–27.

    PubMed  CAS  Google Scholar 

  43. Evans HL. Columnar-cell carcinoma of the thyroid. A report of two cases of an aggressive variant of thyroid carcinoma. Am J Clin Pathol 1986;85:77–80.

    PubMed  CAS  Google Scholar 

  44. Sobrinho-Simôes M, Nesland J, Johannessen J. Columnar-cell carcinoma. Another variant of poorly differentiated carcinoma of the thyroid. Am J Clin Pathol 1988;89:264–267.

    PubMed  Google Scholar 

  45. Berends D. Mouthaan PJ. Columnar-cell carcinoma of the thyroid. Histopathology 1992;20:36–42.

    Google Scholar 

  46. Mizukami Y, Nonomura A, Michigishi T, Noguchi M, Nakamura S, Hashimoto T. Columnar cell carcinoma of the thyroid gland: a case report and review of the literature. Hum Pathol 1994;25:1098–1101.

    PubMed  CAS  Google Scholar 

  47. Gaertner EM, Davidson M, Wenig BM. The columnar cell variant of papillary carcinoma. Case report and discussion of an unusually aggressive thyroid papillary carcinoma. Am J Surg Pathol 1995;19:940–947.

    PubMed  CAS  Google Scholar 

  48. Akslen LA, Varhaug JE. Thyroid carcinoma with mixed tall-cell and columnar-cell features. Am J Clin Pathol 1990;94:442–445.

    PubMed  CAS  Google Scholar 

  49. Wenig BM, Thompson LDR, Adair CF, Heffess CS. Columnar cell variant of thyroid papillary carcinoma. Mod Pathol 1995;8:56A.

    Google Scholar 

  50. Evans HL. Encapsulated columnar-cell neoplasms of the thyroid. A report of four cases suggesting a favorable prognosis. Am J Surg Pathol 1996;20:1205–1211.

    PubMed  CAS  Google Scholar 

  51. Berho M, Suster S. The oncocytic variant of papillary carcinoma of the thyroid: a clinicopathologic study of 15 cases. Hum Pathol 1997;28:47–53.

    PubMed  CAS  Google Scholar 

  52. Herrera MF, Hay ID, Wu PS-C, Goellner JR, Ryan JJ, Ebersold JR, Bergstralh EJ, Grant CS. Hiirthle cell (oxyphilic) papillary carcinoma of the thyroid: a variant with more aggressive biologic behavior. World J Surg 1992;16:669–675.

    PubMed  CAS  Google Scholar 

  53. Barbuto D, Carcangiu ML, Rosai J. Papillary Hiirthle cell neoplasms of the thyroid gland. A study of 20 cases. Mod Pathol 1990;3:7A.

    Google Scholar 

  54. Joensuu H, Klemi P, Eerola E. DNA aneuploidy in follicular adenomas of the thyroid gland. Am J Pathol 1986;124:373–376.

    PubMed  CAS  Google Scholar 

  55. Hostetter AL, Hrafnkelsson J, Wingren SO, Enestrom S, Jordenskjöld B. A comparative study of DNA cytometry methods for benign and malignant thyroid tissue. Am J Clin Pathol 1988;89:760–763.

    PubMed  CAS  Google Scholar 

  56. Hruban RH, Huvos AG, Traganos F, Reuter V, Leiberman PH, Melamed MR. Follicular neoplasms of the thyroid in men older than 50 years of age. A DNA flow cytometric study. Am J Clin Pathol 1990;94:527–532.

    PubMed  CAS  Google Scholar 

  57. Carney JA, Ryan J, Goellner JR. Hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol 1987;11:583–591.

    PubMed  CAS  Google Scholar 

  58. Li M, Carcangiu ML, Rosai J. Abnormal intracellular and extracellular distribution of basement membrane material in papillary carcinoma and hyalinizing trabecular tumors of the thyroid: implications for deregulation of secretory pathways. Hum Pathol 1997;28:1366–1372.

    PubMed  CAS  Google Scholar 

  59. Katoh R, Jasani B, Williams ED. Hyalinizing trabecular adenoma of the thyroid. A report of three cases with immunohistochemical and ultrastructural studies. Histopathology 1989;15:211–224.

    PubMed  CAS  Google Scholar 

  60. Bronner MP, LiVolsi VA, Jennings TA. Plat: paraganglioma-like adenomas of the thyroid. Surg Pathol 1988;1:383–389.

    Google Scholar 

  61. Molberg K, Albores-Saavedra J. Hyalinizing trabecular carcinoma of the thyroid gland. Hum Pathol 1994;25:192–197.

    PubMed  CAS  Google Scholar 

  62. Hazard JB, Kenyon R. Atypical adenoma of the thyroid. Arch Pathol 1954;58:554–563.

    CAS  Google Scholar 

  63. LiVolsi VA, Asa SL. The demise of follicular carcinoma of the thyroid. Thyroid 1994;4:233–236.

    PubMed  CAS  Google Scholar 

  64. Cuello C, Correa P, Eisenberg H. Geographic pathology of thyroid carcinoma. Cancer 1969;23:230–239.

    PubMed  CAS  Google Scholar 

  65. Belfiore A, LaRosa GL, Padova G, Sava L, Ippolito O, Vigneri R. The frequency of cold thyroid nodules and thyroid malignancies in patients from an iodine-deficient area. Cancer 1987;60:3096–3102.

    PubMed  CAS  Google Scholar 

  66. Franssila KO, Ackerman LV, Brown CL, Hedinger CE. Follicular carcinoma. Semin Diagn Pathol 1985;2:101–122.

    PubMed  CAS  Google Scholar 

  67. Carcangiu ML, Zampi G, Rosai J. Poorly differentiated (“insular”) thyroid carcinoma: A reinterpretation of Langhans’ “wuchernde Struma”. Am J Surg Pathol 1984;8:655–668.

    PubMed  CAS  Google Scholar 

  68. Massin JP, Savoie JC, Gamier H, Guiraudon G, Leger FA, Bacourt F. Pulmonary metastasis in differentiated thyroid carcinoma. Study of 58 cases with implications for the primary tumor treatment. Cancer 1984;53:982–992.

    PubMed  CAS  Google Scholar 

  69. Evans HL. Follicular neoplasms of the thyroid. Cancer 1984;54:535–540.

    PubMed  CAS  Google Scholar 

  70. Nagamine Y, Suzuki J, Katakura R, Yoshimoto T, Matoba N, Takaya K. Skull metastasis of thyroid carcinoma. Study of 12 cases. J Neurosurg 1985;63:526–531.

    PubMed  CAS  Google Scholar 

  71. Lang W, Choritz H, Hundeshagen H. Risk factors in follicular thyroid carcinomas. A retrospective follow-up study covering a 14-year period with emphasis on morphological findings. Am J Surg Pathol 1986;10:246–255.

    PubMed  CAS  Google Scholar 

  72. Simpson WJ, McKinney SE, Carruthers JS, Gospodarowicz MK, Sutcliffe SB, Panzarella T. Papillary and follicular thyroid carcinoma. Prognostic factors in 1,578 patients. Am J Med 1987;83:479–488.

    PubMed  CAS  Google Scholar 

  73. Shaha AR, Loree TR, Shah JP. Prognostic factors and risk group analysis in follicular carcinoma of the thyroid. Surg 1995;118:1131–1136.

    CAS  Google Scholar 

  74. Hürthle K. Beitrage zur Kenntiss der Secretionsvorgangs in der Schilddruse. Arch Gesamte Physiol 1894;56:1–44.

    Google Scholar 

  75. Bronner MP, LiVolsi VA. Oxyphilic (Askanazy/Hürthle cell) tumors of the thyroid: microscopic features predict biologic behavior. Surg Pathol 1988;1:137–150.

    Google Scholar 

  76. Watson RG, Brennen MD, Goellner JR, van Heerden JA, McConahey WM, Taylor WF. Invasive Hürthle cell carcinoma of the thyroid: natural history and management. Mayo Clin Proc 1984;59:851–855.

    PubMed  CAS  Google Scholar 

  77. Carcangiu ML, Bianchi S, Savino D, Voynick IM, Rosai J. Follicular Hürthle cell neoplasms of the thyroid gland. A study of 153 cases. Cancer 1991;68:1944–1953.

    PubMed  CAS  Google Scholar 

  78. Tollefsen HR, Shah JP, Huvos AG. Htirthle cell carcinoma of the thyroid. Am J Surg 1975;130:390–394.

    PubMed  CAS  Google Scholar 

  79. Evans HL, Vassilopoulou R. Hurthle cell and follicular carcinomas of the thyroid: a comparative study. Mod Pathol 1998;11:56A.

    Google Scholar 

  80. Apel RL, Asa SL, LiVolsi VA. Papillary Hürthle cell carcinoma with lymphocytic stroma: “Warthin-like tumor” of the thyroid. Am J Surg Pathol 1995;19:810–814.

    PubMed  CAS  Google Scholar 

  81. Langhans T. Über die epithelialen Formen der malignen Struma. Virchows Arch Pathol Anat 1907;189:69–188.

    Google Scholar 

  82. Meissner WA, Warren S. Tumors of the thyroid gland. Washington: Armed Forces Institute of Pathology, 1969.

    Google Scholar 

  83. Papotti M, Botto Micca F, Favero A, Palestini N, Bussolati G. Poorly differentiated thyroid carcinomas with primordial cell component. A group of aggressive lesions sharing insular, trabecular, and solid patterns. Am J Surg Pathol 1993;17:291–301.

    PubMed  CAS  Google Scholar 

  84. Pilotti S, Collini P, Mariani L, Placucci M, Bongarzone I, Vigneri P, Cipriani S, Falcetta F, Miceli R, Pierotti MA, Rilke F. Insular carcinoma. A distinct de novo entity among follicular carcinomas of the thyroid gland. Am J Surg Pathol 1997;21:1466–1473.

    PubMed  CAS  Google Scholar 

  85. Flynn SD, Forman BH, Stewart AF, Kinder BK. Poorly differentiated (“insular”) carcinoma of the thyroid gland: an aggressive subset of differentiated thyroid neoplasms. Surgery 1988;104:963–970.

    PubMed  CAS  Google Scholar 

  86. Killeen RM, Barnes L, Watson CG, Marsh WL, Chase DW, Schuller DE. Poorly differentiated (`insular’) thyroid carcinoma. Arch Otolaryngol Head Neck Surg 1990;116:1082–1086.

    PubMed  CAS  Google Scholar 

  87. Pilotti S, Collini P, Del Bo R, Cattoretti G, Pierotti MA, Rilke F. A novel panel of antibodies that segregates immunocytochemically poorly differentiated carcinoma from undifferentiated carcinoma of the thyroid gland. Am J Surg Pathol 1994;18:1054–1064.

    PubMed  CAS  Google Scholar 

  88. Carr K, Heffess C, Jin L, Lloyd R. Immunohistochemical analysis of thyroid carcinomas utilizing antibodies to p53 and Ki-67. Applied Immunohistochemistry 1993; 1:201–207.

    Google Scholar 

  89. Dobashi Y, Sakamoto A, Sugimura H, Mernyei M, Mori M, Oyama T, Machinami R. Overexpression of p53 as a possible prognostic factor in human thyroid carcinoma. Am J Surg Pathol 1993;17:375–381.

    PubMed  CAS  Google Scholar 

  90. Soares P, Cameselle-Teijeiro J, Sobrinho-Simoes M. Immunohistochemical detection of p53 in differentiated, poorly differentiated and undifferentiated carcinomas of the thyroid. Histopathology 1994;24:205–210.

    PubMed  CAS  Google Scholar 

  91. Sakamoto A, Kasai N, Sugano H. Poorly differentiated carcinoma of the thyroid. A clinicopathologic entity for a high-risk group of papillary and follicular carcinomas. Cancer 1983;52:1849–1855.

    PubMed  CAS  Google Scholar 

  92. Sobrinho-Simoes M. Tumours of thyroid: a brief overview with emphasis on the most controversial issues. Curr Diag Pathol 1995;2:15–22.

    Google Scholar 

  93. Carcangiu ML, Steeper T, Zampi G, Rosai J. Anaplastic thyroid carcinoma. A study of 70 cases. Am J Clin Pathol 1985;83:135–158.

    PubMed  CAS  Google Scholar 

  94. Nel CJC, van Heerden JA, Goellner JR, Gharib H, McConahey WM, Taylor WM, Grant CS. Anaplastic carcinoma of the thyroid: a clinicopathologic study of 82 cases. Mayo Clin Proc 1985;60:51–58.

    PubMed  CAS  Google Scholar 

  95. Rosai J, Saxen EA, Woolner L. Undifferentiated and poorly differentiated carcinoma. Sem Diag Pathol 1985;2:123–136.

    CAS  Google Scholar 

  96. Venkatesh YSS, Ordonez NG, Schultz PN, Hickey RC, Goefert H, Samaan NA. Anaplastic carcinoma of the thyroid. A clinicopathologic study of 121 cases. Cancer 1990;66:321–330.

    PubMed  CAS  Google Scholar 

  97. Gaffey MJ, Lack EE, Christ ML, Weiss LM. Anaplastic thyroid carcinoma with osteoclast-like giant cells. A clinicopathologic, immunohistochemical, and ultrastructural study. Am J Surg Pathol 1991;15:160–168.

    PubMed  CAS  Google Scholar 

  98. Miettinen M, Franssila K, Lehto V-P, Paasivuo R, Virtanen I. Expression of intermediate filament proteins in thyroid gland and thyroid tumors. Lab Invest 1984;50:262–270.

    PubMed  CAS  Google Scholar 

  99. Hurlimann J, Gardiol D, Scazziga B. Immunohistology of anaplastic thyroid carcinoma. A study of 43 cases. Histopathology 1987;11:567–580.

    PubMed  CAS  Google Scholar 

  100. Ordóñez NG, el-Naggar AK, Hickey RC, Samaan NA. Anaplastic thyroid carcinoma. Immunocytochemical study of 32 cases. Am J Clin Pathol 1991;96:15–24.

    PubMed  Google Scholar 

  101. LiVolsi VA, Brooks JJ, Arendash-Durand B. Anaplastic thyroid tumors: immunohistology. Am J Clin Pathol 1987;87:434–442.

    PubMed  CAS  Google Scholar 

  102. Wilson NW, Pambakian H, Richardson TC, Stokoe MR, Makin CA, Heyderman E. Epithelial markers in thyroid carcinoma: an immunoperoxidase study. Histopathology 1986;10:815–829.

    PubMed  CAS  Google Scholar 

  103. Albores-Saavedra J, Nadji M, Civantos F, Morales AR. Thyroglobulin in carcinoma of the thyroid: an immunohistochemical study. Hum Pathol 1983;14:62–66.

    PubMed  CAS  Google Scholar 

  104. Ryff-de Leche A, Staub JJ, Kohler-Faden R, Muller-Brand J, Heitz PU. Thyroglobulin production by malignant thyroid tumors. An immunocytochemical and radioimmunoassay study. Cancer 1986;57:1145–1153.

    PubMed  CAS  Google Scholar 

  105. Hazard JB, Crile G Jr, Dinsmore RS, Hawk WA, Kenyon R. Neoplasms of the thyroid; classification, morphology, and treatment. Arch Pathol 1955;59:502–513.

    CAS  Google Scholar 

  106. Hazard JB, Hawk WA, Crile G Jr. Medullary (solid) carcinoma of the thyroid - a clinicopathologic entity. J Clin Endocrinol Metab 1959;19:152–161.

    PubMed  CAS  Google Scholar 

  107. Jaquet J. Ein Fall von metastasierenden Amyloidtumoren (Lymphosarkom). Virchows Arch Pathol Mat 1906;185:251–268.

    Google Scholar 

  108. Stoffel E. Lokales Amyloid der Schilddrüse. Virchows Arch Pathol Mat 1910;210:245–252.

    Google Scholar 

  109. Horn RC Jr. Carcinoma of the thyroid. Description of a distinctive morphological variant and report of seven cases. Cancer 1951;4:697–707.

    Google Scholar 

  110. Williams ED. Histogenesis of medullary carcinoma of the thyroid. J Clin Path 1966;19:114–118.

    PubMed  CAS  Google Scholar 

  111. Meyer JS, Abdel-Bari W. Granules and thyrocalcitonin like activity in medullary carcinoma of the thyroid gland. N Engl J Med 1968;278:523–529.

    PubMed  CAS  Google Scholar 

  112. Bussolati G, Foster GV, Clark MB, Pearse AGE. Immunofluorescent localisation of calcitonin in medullary (c cell) thyroid carcinoma, using antibody to the pure porcine hormone. Virchows Arch Abt Zellpath 1969;2:234–238.

    CAS  Google Scholar 

  113. Ledger GA, Khosla S, Lindor NM, Thibodeau, Gharib H. Genetic testing in the diagnosis and management of multiple endocrine neoplasia type II. Ann Intern Med 1995;122–118–124.

    Google Scholar 

  114. Eng C, Clayton D, Schuffenecker I, Lenoir G, Cote G, Gagel RF, van Amstel HKP, Lips CJM, Nishisho I, Takai S-I, Marsh DJ, Robinson BG, Frank-Raue K, Raue F, Xue F, Noll WW, Romei C, Pacini F, Fink M, Niederle B, Zedenius J, Nordenskjöld M, Komminoth P, Hendy GN, Gharib H, Thibodeau SN, Lacroix A, Frilling A, Ponder BM, Mulligan LM. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. JAMA 1996;276:1575–1579.

    PubMed  CAS  Google Scholar 

  115. Uribe M, Grimes M, Fenoglio-Preiser CM, Feind C. Medullary carcinoma of the thyroid gland. Clinical, pathological, and immunocytochemical features with review of the literature. Am J Surg Pathol 1985;9:577–594.

    PubMed  CAS  Google Scholar 

  116. Sikri KL, Varndell IM, Hamib QA, Wilson BS, Kameya T, Ponder BAJ, Lloyd RV, Bloom SR, Polak JM. Medullary carcinoma of the thyroid. An immunocytochemical and histochemical study of 25 cases using eight separate markers. Cancer 1985;56:2481–2491.

    PubMed  CAS  Google Scholar 

  117. Steenbergh PH, Höppener JW, Zandberg J, van de Ven WJ, Jansz HS, Lips CJ. Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma. J Clin Endocrinol Metab 1984;59:358–360.

    PubMed  CAS  Google Scholar 

  118. Schröder S, Böcker W, Baisch H, Bürk CG, Arps H, Meiners I, Kastendieck H, Heitz PU, Klöppel G. Prognostic factors in medullary thyroid carcinoma. Survival in relation to age, sex, stage, histology, immunocytochemistry, and DNA content. Cancer 1988;61:806–816.

    PubMed  Google Scholar 

  119. Santa G. Carcangiu ML, Rosai J. The biochemical and immunohistochemical profile of thyroid neoplasia. Pathol Annu 1988;23:129–157.

    Google Scholar 

  120. de Micco C, Chapel F, Dor A-M, Garcia S, Ruf J, Carayon P, Henry J-F, Lebreuil G. Thyroglobulin in medullary carcinoma: immunohistochemical study with polyclonal and monoclonal antibodies. Hum Pathol 1993;24:256–262.

    PubMed  Google Scholar 

  121. Hales M, Rosenau W, Okerlund MD, Galante M. Carcinoma of the thyroid with a mixed medullary and follicular pattern: morphologic, immunohistochemical and clinical laboratory studies. Cancer 1982;50:1352–1359.

    PubMed  CAS  Google Scholar 

  122. Pflatz M, Hedinger CH, Muhlethaler JP. Mixed medullary and follicular carcinoma of the thyroid. Virchows Arch (A) 1983;400:53–59.

    Google Scholar 

  123. Ljungberg O, Bondeson L, Bondeson A-G. Differentiated thyroid carcinoma, intermediate type: a new tumor entity with features of follicular and parafollicular cell carcinoma. Hum Pathol 1984;15:218–228.

    PubMed  CAS  Google Scholar 

  124. Albores-Saavedra J, Gorraez de la Mora T, de la Torre-Rendon F, Gould E. Mixed medullary-papillary carcinoma of the thyroid: a previously unrecognized variant of thyroid carcinoma. Hum Pathol 1990;21:1151–1155.

    PubMed  CAS  Google Scholar 

  125. Heshmati HM, Gharib H, van Heerden JA, Sizemore GW. Advances and controversies in the diagnosis and management of medullary thyroid carcinoma. Am J Med 1997;103:60–69.

    PubMed  CAS  Google Scholar 

  126. Brierly J, Tsang R, Simpson WJ, Gospadarowicz M, Sutcliffe S, Panzarella T. Medullary thyroid carcinoma: analyses of survival and prognostic factors and the role of radiation therapy in local control. Thyroid 1996;6:305–310.

    Google Scholar 

  127. Bergholm V, Adami H-O, Auer G, Bergstrom R, Bäckdahl M, Grimelius L, Hansson G, Ljungberg O, Wilander E. Histopathologic characteristics and nuclear DNA content as prognostic factors in medullary thyroid carcinoma. A nationwide study in Sweden. Cancer 1989;64:135–142.

    PubMed  CAS  Google Scholar 

  128. Viale G, Roncalli M, Grimelius L, Graziani D, Wilander E, Johansson H, Bergholm U, Coggi G. Prognostic value of Bc1–2 immunoreactivity in medullary thyroid carcinoma. Hum Pathol 1995;26:945–950.

    PubMed  CAS  Google Scholar 

  129. Saad MF, Ordonez NG, Rashid RK, Guido JJ, Hill CS Jr, Hickey RC, Samaar NA. Medullary carcinoma of the thyroid: a study of the clinical features and prognostic factors in 161 patients. Medicine 1984;63:319–342.

    PubMed  CAS  Google Scholar 

  130. Dottorini ME, Assi A, Sironi M, Sangalli G, Spreafico G, Columbo L. Multivariate analysis of patients with medullary thyroid carcinoma. Prognostic significance and impact on treatment of clinical and pathologic variables. Cancer 1996;77:1556–1565.

    PubMed  CAS  Google Scholar 

  131. Heimann R, Vannineuse A, De Sloover C, Dor P. Malignant lymphomas and undifferentiated small carcinomas of the thyroid: a clinicopathologic review in the light of the Kiel classification for malignant lymphomas. Histopathology 1978;2:201–213.

    PubMed  CAS  Google Scholar 

  132. Compagno J, Oertel JE. Malignant lymphoma and other lymphoproliferative disorders of the thyroid gland. A clinicopathologic study of 245 cases. Am J Clin Pathol 1980;74:1–11.

    PubMed  CAS  Google Scholar 

  133. Oertel JE. Heffess CS. Lymphoma of the thyroid and related disorders. Semin Oncol 1987;14:333–342.

    PubMed  CAS  Google Scholar 

  134. Thompson LDR, Derringer GA, Abbondanzo SI, Heffess CS. Primary malignant lymphomas of the thyroid gland: A clinicopathologic study of 109 cases. Modem Pathol 1998;11:59A.

    Google Scholar 

  135. Allevato PA, Kini SR, Rebuck JW, Miller JM, Hamburger JI. Signet ring cell lymphoma of the thyroid: a case report. Hum Pathol 1985;16:1066–1068.

    PubMed  CAS  Google Scholar 

  136. McDermott EWM, Cassidy N, Heffernan SJ. Perforation through undiagnosed small bowel involvement in primary thyroid lymphoma during chemotherapy. Cancer 1992;69:572–573.

    PubMed  CAS  Google Scholar 

  137. Stone CW, Slease RB, Brubaker D, Fabian C, Grozea PN. Thyroid lymphoma with gastrointestinal involvement: report of three cases. Am J Hematol 1986;21:357–365.

    PubMed  CAS  Google Scholar 

  138. Devine RM, Edis M, Banks PM. Primary lymphoma of the thyroid: a review of the Mayo Clinic experience through 1978. World J Surg 1981;5:33–38.

    PubMed  CAS  Google Scholar 

  139. Aozasa K, Inoue A, Tajima K, Miyauchi A, Matsuzuka F, Kuma K. Malignant lymphoma of the thyroid gland. Analysis of 79 patients with emphasis on histologic prognostic factors. Cancer 1986;58:100–104.

    PubMed  CAS  Google Scholar 

  140. Matsuzuka F, Miyauchi A, Katayama S, Norabayashi I, Ikeda H, Kuma K, Sugawara M. Clinical aspects of primary thyroid lymphoma: diagnosis and treatment based on our experience of 119 cases. Thyroid 1993;3:93–99.

    PubMed  CAS  Google Scholar 

  141. Doria R, Jekel JF, Cooper D. The case for combined modality therapy. Cancer 1994;73:200–206.

    PubMed  CAS  Google Scholar 

  142. LaGuette J, Matias-Guiu X, Rosai J. Thyroid paraganglioma: a clinicopathologic and immunohistochemical study of three cases. Am J Surg Pathol 1997;21:748–753.

    PubMed  CAS  Google Scholar 

  143. Wenig BM, Adair CF, Heffess CS. Primary mucoepidermoid carcinoma of the thyroid gland: a report of six cases and a review of the literature of a follicular epithelial-derived tumor. Hum Pathol 1995;26:1099–1108.

    PubMed  CAS  Google Scholar 

  144. Chan JKC, Albores-Saavedra J, Battifora H, Carcangiu ML, Rosai J. Sclerosing mucoepidermoid thyroid carcinoma with eosinophilia. A distinctive low-grade malignancy arising from the metaplastic follicles of Hashimoto’s thyroiditis. Am J Surg Pathol 1991;15:438–448.

    PubMed  CAS  Google Scholar 

  145. Sim SJ, Ro JY, Ordonez NG, Cleary KR, Ayala AG. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: report of two patients, one with distant metastasis, and review of the literature. Hum Pathol 1997;28:1091–1096.

    PubMed  CAS  Google Scholar 

  146. Hedinger CE. Geographic pathology of thyroid diseases. Pathol Res Pract 1981;171:285–292.

    PubMed  CAS  Google Scholar 

  147. Chan JKC, Rosai J. Tumors of the neck showing thymic or related branchial pouch differentiation: a unifying concept. Hum Pathol 1991;22:349–367.

    PubMed  CAS  Google Scholar 

  148. Ivy HK, Cancer metastatic to the thyroid: a diagnostic problem. Mayo Clin Proc 1984;59:856–859.

    PubMed  CAS  Google Scholar 

  149. Ro JY, Guerrieri C, el-Naggar AK, Ordonez NG, Sorge JG, Ayala AG. Carcinomas metastatic to follicular adenomas of the thyroid gland. Report of two cases. Arch Pathol Lab Med 1994;118:551–556.

    PubMed  CAS  Google Scholar 

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  1. University of Cincinnati, Cincinnati, Ohio, USA

    Paul Biddinger MD & Yuri E. Nikiforov MD,PhD

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  1. Division of Endocrinology & Metabolism Department of Medicine College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA

    James A. Fagin

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Biddinger, P., Nikiforov, Y.E. (1998). Pathologic Features of Thyroid Tumors. In: Fagin, J.A. (eds) Thyroid Cancer. Endocrine Updates, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4945-1_5

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