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Antisense Approaches to Investigate the Neuroendocrine Control of Thirst and Sodium Appetite in The Rat

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Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning

Part of the book series: Perspectives in Antisense Science ((DARE,volume 1))

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Abstract

Investigations in the area of behavioral neuroendocrinology have typically employed traditional approaches to discerning the sites of action of these hormones in the brain. These techniques used in examining the mechanisms governing thirst and sodium appetite have included selective electrolytic and chemical lesions, electrophysiological recording and application of hormone agonists or antagonists to their receptor proteins in the brain (Simpson et al., 1978; Zhang et al., 1993; Nitabach et al., 1989; Fluharty and Epstein, 1983; Fluharty and Sakai, 1995; Fregly and Rowland, 1994; Stricker and Verbalis, 1987; Sakai et al., 1986). The recent cloning of many preprohormones and the genes that encode for their receptors has ushered in a new period of molecular investigation of hormone action. The development of antisense oligonucleotide technology represents one of the most exciting of these new developments and is rapidly gaining acceptance in neuroendocrinology since the early publications describing the power of antisense oligodeoxynucleotides (ODNs) and their potential as possible therapeutic agents (Marcus-Sekura, 1988; Uhlmann and Peyman, 1990).

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Authors
  1. Randall R. Sakai
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  2. Li Yun Ma
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  3. Steven J. Fluharty
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Editor information

Editors and Affiliations

  1. University of Maryland, Baltimore, USA

    Margaret M. McCarthy

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© 1998 Springer Science+Business Media New York

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Sakai, R.R., Ma, L.Y., Fluharty, S.J. (1998). Antisense Approaches to Investigate the Neuroendocrine Control of Thirst and Sodium Appetite in The Rat. In: McCarthy, M.M. (eds) Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning. Perspectives in Antisense Science, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4933-8_8

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  • DOI: https://doi.org/10.1007/978-1-4615-4933-8_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7238-7

  • Online ISBN: 978-1-4615-4933-8

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