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Effects of Dopamine Receptor Antisense RNA Expression Vectors in The Nervous System

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Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning

Part of the book series: Perspectives in Antisense Science ((DARE,volume 1))

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Abstract

As in any new field of scientific inquiry, particularly one that has the potential for providing revolutionary advances in our knowledge of the theoretical as well as practical aspects of therapy, the use of antisense strategies to study biological events has been met understandably with a great deal of enthusiasm and properly with an equal degree of skepticism. One of the purposes of this paper is to review some of the data which we hope will add to the enthusiasm for antisense approaches and to provide additional data which we hope will allay some of the skepticism associated with this field. Although it is tempting to state that investigations in this field should have no greater or lesser burden required of them to prove the validity of their hypotheses than those in other fields, the enormous potential of these molecular biological approaches compels us to be more rigorous in the design and conduct of the experiments and more cautious in our interpretation of the data than one would ordinarily be when conducting experiments which do not have such far reaching implications.

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Authors
  1. Genoveva Davidkova
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  2. Sui-Po Zhang
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  3. Long-Wu Zhou
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  4. Benjamin Weiss
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Editor information

Editors and Affiliations

  1. University of Maryland, Baltimore, USA

    Margaret M. McCarthy

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Davidkova, G., Zhang, SP., Zhou, LW., Weiss, B. (1998). Effects of Dopamine Receptor Antisense RNA Expression Vectors in The Nervous System. In: McCarthy, M.M. (eds) Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning. Perspectives in Antisense Science, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4933-8_5

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  • DOI: https://doi.org/10.1007/978-1-4615-4933-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7238-7

  • Online ISBN: 978-1-4615-4933-8

  • eBook Packages: Springer Book Archive

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