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Concept, Design, and Preclinical Evaluation of Quinolonyl Lactam Antibacterials

  • Chapter
Resolving the Antibiotic Paradox

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 456))

Abstract

The issue of bacterial resistance to current classes of antibiotics is now well known and widely published (Levy, 1998; Chin and Marx, 1994). Indeed, unbeatable contagious infectious diseases have already generated significant medical crises in localized environments. Such crises may become more widespread, perhaps in the not too distant future. Laboratories worldwide have responded with highly creative research programs, many of which are reviewed in this book. Nonetheless, the successful discovery, development, and commercialization of new therapies that address bacterial resistance have proved challenging.

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Authors and Affiliations

  1. Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, Ohio, 45040, USA

    Paul M. Hershberger & Thomas P. Demuth Jr.

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  1. Paul M. Hershberger
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  2. Thomas P. Demuth Jr.
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  1. Wayne State University, Detroit, Michigan, USA

    Barry P. Rosen  & Shahriar Mobashery  & 

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© 1998 Springer Science+Business Media New York

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Hershberger, P.M., Demuth, T.P. (1998). Concept, Design, and Preclinical Evaluation of Quinolonyl Lactam Antibacterials. In: Rosen, B.P., Mobashery, S. (eds) Resolving the Antibiotic Paradox. Advances in Experimental Medicine and Biology, vol 456. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4897-3_13

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  • DOI: https://doi.org/10.1007/978-1-4615-4897-3_13

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