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Design, Synthesis, and Evaluation of Novel Oxazolidinone Antibacterial Agents Active Against Multidrug-Resistant Bacteria

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Resolving the Antibiotic Paradox

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 456))

Abstract

Throughout the human experience, diseases caused by pathogenic bacteria have exerted an enormous negative impact on society. Today, for example, approximately one third of the world’s population is infected with Mycobacterium tuberculosis and tuberculosis remains the leading cause of death in the world from infectious disease (Bloom, 1994). The emergence of effective antibacterial agents, from penicillin to more contemporary drugs, was initially thought to mark an end to the burden of microbial disease. However, subsequent events have illustrated the resiliency of bacteria to environmental pressures, including the threat of antibacterial agents.

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Authors and Affiliations

    Authors
    1. Michael R. Barbachyn
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    2. Steven J. Brickner
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    3. Robert C. Gadwood
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    4. Stuart A. Garmon
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    5. Kevin C. Grega
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    6. Douglas K. Hutchinson
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    7. Kiyotaka Munesada
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    8. Robert J. Reischer
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    9. Mikio Taniguchi
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    10. Lisa M. Thomasco
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    11. Dana S. Toops
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    12. Hiromi Yamada
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    13. Charles W. Ford
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    14. Gary E. Zurenko
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    1. Wayne State University, Detroit, Michigan, USA

      Barry P. Rosen  & Shahriar Mobashery  & 

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    Barbachyn, M.R. et al. (1998). Design, Synthesis, and Evaluation of Novel Oxazolidinone Antibacterial Agents Active Against Multidrug-Resistant Bacteria. In: Rosen, B.P., Mobashery, S. (eds) Resolving the Antibiotic Paradox. Advances in Experimental Medicine and Biology, vol 456. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4897-3_12

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    • DOI: https://doi.org/10.1007/978-1-4615-4897-3_12

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