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DNA-Based Immunization

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Book cover Blood Cell Biochemistry

Part of the book series: Blood Cell Biochemistry ((BLBI,volume 8))

Abstract

DNA vaccines belong to the new technology of nucleic acid-based immunization, also known as genetic immunization. This describes the induction of an immune response to an antigenic protein expressed in vivo after introducing its encoding polynucleotide. In theory, the encoding sequences can be in the form of either DNA or mRNA. However, in practice there are very few RNA vaccines (e.g., Conry et al., 1995a; Martinon et al., 1993), probably because expression is too shortlived to be effective. Thus, most models of nucleic acid-based immunization described to date have used DNA, most often in the form of double-stranded, closed, circular plasmid DNA.

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Authors and Affiliations

  1. Loeb Health Research Institute, Ottawa Civic Hospital, Ottawa, Ontario, K1Y 4E9, Canada

    Heather L. Davis & Cynthia L. Brazolot Millan

  2. Faculties of Health Sciences and Medicine, University of Ottawa, Ottawa, Canada

    Heather L. Davis

Authors
  1. Heather L. Davis
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  2. Cynthia L. Brazolot Millan
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Editors and Affiliations

  1. Christie CRC Research Centre Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK

    Leslie J. Fairbairn  & Nydia G. Testa  & 

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© 1999 Springer Science+Business Media New York

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Davis, H.L., Millan, C.L.B. (1999). DNA-Based Immunization. In: Fairbairn, L.J., Testa, N.G. (eds) Blood Cell Biochemistry. Blood Cell Biochemistry, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4889-8_14

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  • DOI: https://doi.org/10.1007/978-1-4615-4889-8_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7218-9

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