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Age-Related Cognitive Decline in the Rhesus Monkey

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Cerebral Cortex

Part of the book series: Cerebral Cortex ((CECO,volume 14))

Abstract

It is only in the last 25 years that significant strides have been taken toward the development of primate models of normal human aging. Together with advances in the fields of molecular biology, neuroimaging, and behavioral neuroscience, these models have emerged as potentially important components in our understanding of the age-related cognitive decline in humans (Peters et al., 1996). This is not to say that studies using other species, particularly rodents, have provided a wealth of information on the neurobiological substrates of aging. However, the rich behavioral repertoire of the monkey, particularly the monkey’s remarkable ability to perform a variety of complex short-term memory tasks, many administered to normal humans in geriatric research studies, has made this species particularly suited to assess cognitive function at a level not possible in nonprimates.

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Authors and Affiliations

  1. Department of Neuroanatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, 02118, USA

    Mark B. Moss & Ronald J. Killiany

  2. Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia, 30322, USA

    James G. Herndon

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  1. Mark B. Moss
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  2. Ronald J. Killiany
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  3. James G. Herndon
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Editors and Affiliations

  1. Boston University School of Medicine, Boston, Massachusetts, USA

    Alan Peters

  2. Mount Sinai Medical Center, New York, New York, USA

    John H. Morrison

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Moss, M.B., Killiany, R.J., Herndon, J.G. (1999). Age-Related Cognitive Decline in the Rhesus Monkey. In: Peters, A., Morrison, J.H. (eds) Cerebral Cortex. Cerebral Cortex, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4885-0_2

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