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Multifocal Cortical Neurodegeneration in Alzheimer’s Disease

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Book cover Cerebral Cortex

Part of the book series: Cerebral Cortex ((CECO,volume 14))

Abstract

Cortical atrophy is well known in Alzheimer’s disease (AD), however, there are different interpretations of its location and extent. Neurodegeneration and atrophy are relatively consistent in medial temporal areas, including hippocampal, entorhinal, and perirhinal cortices, and they follow a uniform pattern. This is not the only region of atrophy, however, since it occurs in prefrontal, parietotemporal, occipital, and cingulate cortices. Furthermore, although gross focal atrophy is not always present, focal neurodegeneration may occur with focal changes in glucose metabolism. The concept of multifocal cortical degeneration leads to the view of multiple structural and functional subsystem disruption in AD.

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Authors and Affiliations

  1. Cingulum Neuro-Sciences Institute, Winston-Salem, North Carolina, 27101, USA

    Brent A. Vogt, Kent E. Vrana, John R. Absher & Leslie J. Vogt

  2. Departments of Physiology, Pharmacology, and Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, 27157-1083, USA

    Brent A. Vogt, Kent E. Vrana, John R. Absher & Leslie J. Vogt

  3. National Institute of Mental Health, Bethesda, Maryland, 20892-1366, USA

    Alex Martin

  4. Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology and Department of Geriatrics and Adult Development, and Department of Opthalmology, Mount Sinai School of Medicine, New York, New York, 10029, USA

    Patrick R. Hof

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  1. Brent A. Vogt
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  2. Alex Martin
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  3. Kent E. Vrana
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  5. Leslie J. Vogt
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  6. Patrick R. Hof
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Editors and Affiliations

  1. Boston University School of Medicine, Boston, Massachusetts, USA

    Alan Peters

  2. Mount Sinai Medical Center, New York, New York, USA

    John H. Morrison

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Vogt, B.A., Martin, A., Vrana, K.E., Absher, J.R., Vogt, L.J., Hof, P.R. (1999). Multifocal Cortical Neurodegeneration in Alzheimer’s Disease. In: Peters, A., Morrison, J.H. (eds) Cerebral Cortex. Cerebral Cortex, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4885-0_16

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  • DOI: https://doi.org/10.1007/978-1-4615-4885-0_16

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