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Neuropathological Correlates of Dementia in Alzheimer’s Disease

  • Chapter
Cerebral Cortex

Part of the book series: Cerebral Cortex ((CECO,volume 14))

Abstract

Memory and learning are fundamental components of cognition. During the course of Alzheimer’s disease (AD) there is a progressive deterioration of these mental functions, resulting in the loss of intellectual and social abilities of the individual (Khachaturian, 1985; Katzman et al, 1988; Terry et al., 1991). Therefore, understanding the basic mechanisms involved in learning and memory is of fundamental importance for understanding the pathogenesis of dementia in AD. Memory formation following learning is presumed to result from modification in the efficacy of neural circuitry, either through strengthening of preexisting synapses, or formation of new contacts (Stewart and Rusakov, 1995). Recent studies postulate that the memory process includes a short-term and a long-term component (Addersen and Trommald, 1995), with the former mediated by the limbic system and the latter involving changes in the neocortex (Andersen and Trommald, 1995).

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Authors and Affiliations

  1. Departments of Neurosciences and Pathology, University of California, San Diego, La Jolla, California, 92093-0624, USA

    Eliezer Masliah

  2. Department of Neurosciences, University of California, San Diego, La Jolla, California, 92093-0948, USA

    David P. Salmon

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  1. Eliezer Masliah
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  1. Boston University School of Medicine, Boston, Massachusetts, USA

    Alan Peters

  2. Mount Sinai Medical Center, New York, New York, USA

    John H. Morrison

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Masliah, E., Salmon, D.P. (1999). Neuropathological Correlates of Dementia in Alzheimer’s Disease. In: Peters, A., Morrison, J.H. (eds) Cerebral Cortex. Cerebral Cortex, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4885-0_15

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