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Temporal Sequence of Alzheimer’s Disease-Related Pathology

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Book cover Cerebral Cortex

Part of the book series: Cerebral Cortex ((CECO,volume 14))

Abstract

Neuropathologic hallmarks of Alzheimer’s disease (AD) include the progressive deposition of virtually insoluble proteinaceous material in both extracellular and intraneuronal locations. The extracellular deposits consist mainly of Aβ-amyloid-protein (Joachim and Selkoe, 1989; Beyreuther and Masters, 1991; Selkoe, 1991, 1993, 1994); abnormally phosphorylated tau protein (PHF-tau, paired helical filament tau) dominates among the intraneuronal changes (Goedert et al., 1991, 1992; Iqbal and Grundke-Iqbal, 1991; Schmidt et al., 1991; Dickson et al., 1992; Goedert, 1993; Iqbal et al., 1993, 1994; Price and Sisodia, 1994; Trojanowski et al., 1995). A variety of other substances accompany both the Aβ-amyloid deposits and the abnormal tau protein.

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  1. Department of Anatomy, J. W. Goethe University, D-60590, Frankfurt, Germany

    Heiko Braak & Eva Braak

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  1. Heiko Braak
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  1. Boston University School of Medicine, Boston, Massachusetts, USA

    Alan Peters

  2. Mount Sinai Medical Center, New York, New York, USA

    John H. Morrison

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Braak, H., Braak, E. (1999). Temporal Sequence of Alzheimer’s Disease-Related Pathology. In: Peters, A., Morrison, J.H. (eds) Cerebral Cortex. Cerebral Cortex, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4885-0_14

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