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Ultrastructural Changes in Dementing Illnesses

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Book cover Cerebral Cortex

Part of the book series: Cerebral Cortex ((CECO,volume 14))

Abstract

Dementia is an organic mental disorder characterized by a general loss of intellectual abilities involving impairment of memory, judgment, and abstract thinking, as well as changes in personality. Because conditions that can cause dementia frequently exhibit characteristic pathological profiles in the brain that can only be adequately detected by electron microscopy (EM), EM has made and is expected to continue making conspicuous contributions to our understanding of the neuropathologies of such conditions. Although there are a lot of dementia-causing illnesses (Tomlinson, 1992), in this review we confine ourselves to typical dementing diseases in which ultrastructural brain changes, both intraneuronal and interstitial, have been intensively investigated.

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Authors and Affiliations

  1. Department of Neurology, Jichi Medical School, Tochigi-ken, 329-0498, Japan

    Imaharu Nakano

  2. Division of Neuropathology, Department of Pathology, Montefiore Medical Center, Bronx, New York, 10467, USA

    Asao Hirano

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  1. Imaharu Nakano
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  2. Asao Hirano
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Editors and Affiliations

  1. Boston University School of Medicine, Boston, Massachusetts, USA

    Alan Peters

  2. Mount Sinai Medical Center, New York, New York, USA

    John H. Morrison

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Nakano, I., Hirano, A. (1999). Ultrastructural Changes in Dementing Illnesses. In: Peters, A., Morrison, J.H. (eds) Cerebral Cortex. Cerebral Cortex, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4885-0_11

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