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Pharmacotherapy and Toxicology of Oppositional Defiant Disorder and Conduct Disorder

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Handbook of Disruptive Behavior Disorders

Abstract

The development of specific treatments for the symptoms of Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) is a priority area for child and adolescent mental health. Antisocial behavior committed by children and adolescents has been on the rise and has been likened to an epidemic (Whitman, Benbow, & Good, 1996). Violence and criminal behavior attributed to adolescents continue to lead to substantial personal and social costs (Yoshikawa, 1994). However, as of yet there are few if any psychosocial treatments that have been clearly shown to reduce the personal and social impacts of juvenile antisocial behavior in a durable and reliable way (see Chapters 22 & 23, this volume). In some areas of child and adolescent psychopathology, pharmacotherapy offers a powerful approach in the treatment of mental disorders, and it is therefore important to look at the value of drug treatment in children with CD.

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References

  • American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.

    Google Scholar 

  • Arnold, L. E., & Aman, M. G. (1991). Beta blockers in mental retardation and developmental disorders.Journal of Child and Adolescent Psychopharmacology, 1, 361–373.

    Google Scholar 

  • Barratt, E. S. (1993). The use of anticonvulsants in aggres sion and violence. Psychopharmacology Bulletin, 29, 75–81.

    PubMed  Google Scholar 

  • Broderick, P., & Lynch, V. (1982). Behavioral and biochemical changes induced by lithium and L-tryptophan in muricidal rats. Neuropharmacology, 21, 671–679.

    Article  PubMed  Google Scholar 

  • Campbell, M., & Cueva, J. E. (1995a). Psychopharmacology in child and adolescent psychiatry: A review of the past seven years: Part I. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 1124–1132.

    Article  Google Scholar 

  • Campbell, M., & Cueva, J. E. (1995b). Psychopharmacology in child and adolescent psychiatry: A review of the past seven years: Part II. Journal of the American Atad-my of Child and Adolescent Psychiatry, 34, 1262–1272.

    Article  Google Scholar 

  • Campbell, M., Small, A. M., Green, W. H., Jennings, S. J., Perry, R., Bennett, W. G., & Anderson, L. (1984). Behavioral efficacy of haloperidol and lithium carbonate: A comparison in hospitalized aggressive children with conduct disorder. Archives of General Psychiatry, 41, 650–656.

    Article  PubMed  Google Scholar 

  • Campbell, M., Gonzalez, N. M., & Silva, R. R. (1992). The pharmacologic treatment of conduct disorders and rage outbursts. Psychiatric Clinics of North America, 15, 69–85.

    PubMed  Google Scholar 

  • Campbell, M., Adams, R. B., Small, A M, Kafantaris, V., Silva, R. R., Shell, J., Perry, R., & Overall, J. E. (1995). Lithium in hospitalized aggressive children with conduct disorder: A double-blind and placebo-controlled study. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 445–453.

    Article  PubMed  Google Scholar 

  • Casat, C. D., Pearson, D. A., Van Davelaar, M. J., & Cherek, D. R. (1995). Methylphenidate effects on a laboratory aggression measure in children with ADHD. Psychopharmacology Bulletin, 31, 353–356.

    PubMed  Google Scholar 

  • Cherek, D. R., Thompson, T., & Kelly, T. (1980). Chronic delta 9-tetrahydrocannabinol administration and schedule-induced aggression. Pharmacology,Biochemistry and Behavior, 12, 305–309.

    Article  Google Scholar 

  • Cloninger, C. R., Svrakic, D. M., & Przybeck, T. R. (1993). A psychobiological model of temperament and character. Archives of General Psychiatry, 50, 975–990.

    Article  PubMed  Google Scholar 

  • Craft, M., Ismail, I. A., Krishnamurti, D., Mathews, J., Regan, A., Seth, R. V., & North, P. M. (1987). Lithium in the treatment of aggression in mentally handicapped patients: A double-blind trial. British Journal of Psychiatry, 150, 685–689.

    Article  PubMed  Google Scholar 

  • Cueva, J. E., Overall, J. E., Small, A. M., Armenteros, J. L, Perry, R., & Campbell, M. (1996). Carbamazepine in aggressive children with conduct disorder: A double-blind and placebo-controlled study. Journal of the American Academy of Child and Adolescent Psychiatry,35,480–490.

    Article  PubMed  Google Scholar 

  • Cutler, M. G., & Mackintosh, J. H. (1984). Cannabis and delta-9-tecrahydrocannabinol. Effects on elements of social behaviour in mice. Neuropharmacology,23,1091–1097.

    Article  Google Scholar 

  • Datla, K. P., Mitra, S. K., & Bhattacharya, S. K. (1991). Serotonergic modulation of footshock induced aggression in paired rats. Indian Journal of Experimental Biology, 29, 631–635.

    PubMed  Google Scholar 

  • Deckel, A. W. (1996). Behavioral changes in Anolis carolinensis following injection with fluoxetine. Behavioural Brain Research,78,175–182.

    Article  PubMed  Google Scholar 

  • Dodman, N. H., Donnelly, R., Shuster, L., Mertens, P., Rand, W, & Miczek, K. (1996). Use of fluoxetine to treat dominance aggression in dogs. Journal of the American Veterinary Medical Association,209,1585–1587.

    Google Scholar 

  • Donovan, S. J., Susser, E. S., Nunes, E. V., Stewart, J. W, Quitkin, F. M., & Klein, D. F. (1997). Divalproex treatment of disruptive adolescents: A report of 10 cases. Journal of Clinical Psychiatry, 58,12–15.

    Article  PubMed  Google Scholar 

  • Eichelman, B. (1992). Aggressive behavior: From laboratory to clinic-Quo vadit? Archives of General Psychiatry, 49, 488–492.

    Article  PubMed  Google Scholar 

  • Emslie G J (1996, October). Pharmacological treatment of early onset major depressive disorder. Paper presented at the scientific proceedings of the annual meeting of the American Academy of Child and Adolescent Psychiatry, Philadelphia.

    Google Scholar 

  • Ernst, M., Malone, R. P., Rowan, A. B., George, R., Gonzalez, N. M., & Silva, R. R. (1998). Antipsychotics (neuroleptics). In J. S. Werry & M. G. Aman (Eds.), A practitioner’s guide to psychoactive drugs for children and adolescents (2nd ed, pp. 297–328). New York: Plenum.

    Google Scholar 

  • Fava, M., Rosenbaum, J. F., Pava, J. A., McCarthy, M. K., Steingard, R. J., & Bouffides, E. (1993). Anger attacks in unipolar depression: Part 1. Clinical correlates and response to fluoxetine treatment. American Journal of Psychiatry, 150, 1158–1163.

    PubMed  Google Scholar 

  • Fujiwara, M., Kataoka, Y., Hori, Y., & Ueki, S. (1984). Irritable aggression induced by delta 9-tetrahydrocannabinol in rats pretreated with 6-hydroxydopamine. Pharmacology, Biochemistry and Behavior, 20, 457–462.

    Article  Google Scholar 

  • Gadow, K. D., Nolan, E. E., Sverd, J., Sprafkin, J., & Paolicelli, L. (1990). Methylphenidate in aggressive-hyperactive boys: I. Effects on peer aggression in public school settings. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 710–718.

    Article  PubMed  Google Scholar 

  • Gawin, F. H., Khalsa, M. E., & Ellinwood, E. (1994). Stimulants. In M. Galanter & H. D. Kleber (Eds.), Textbook of substance abuse treatment (pp. 111–140). Washington, DC: American Psychiatric Press.

    Google Scholar 

  • Glenn, M. B., Wroblewski, B., Parziale, J., Levine, L., Whyte, J., & Rosenthal, M. (1989). Lithium carbonate for aggressive behavior or affective instability in ten brain-injured patients. American Journal of Physical Medicine and Rehabilitation, 68, 221–226.

    Article  PubMed  Google Scholar 

  • Gray, J. A. (1982a). The neuropsychology of anxiety: An inquiry into the function of the septo-hippocampal system. New York: Oxford University Press.

    Google Scholar 

  • Gray, J. A. (1982b). The neuropsychology of anxiety: An inquiry into the functions of the septo-hippocampal system. Behavioral and Brain Sciences, 5, 469–534.

    Article  Google Scholar 

  • Gray, J. A. (1987a). Perspectives on anxiety and impulsivity: A commentary. Journal of Research in Personality, 21, 493–509.

    Article  Google Scholar 

  • Gray, J. A. (1987b). The psychology of fear and stress. New York: Cambridge University Press.

    Google Scholar 

  • Hinshaw, S. P., Henker, B., Whalen, C. K., Erhardt, D., & Dunnington, R. E., Jr. (1989). Aggressive, prosocial, and nonsocial behavior in hyperactive boys: Dose effects of methylphenidate in naturalistic settings. Journal of Consulting and Clinical Psychology, 57, 636–643.

    Article  PubMed  Google Scholar 

  • Horrigan, J. P., & Barnhill, L. J. (1995). Guanfacine for treatment of Attention Deficit Hyperactivity Disorder. Journal of Child and Adolescent Psychopharmacology, 5, 215–223.

    Article  Google Scholar 

  • Hunt, R. D., Capper, L, & O’Connell, P. (1990). Clonidine in child and adolescent psychiatry. Journal of Child and Adolescent Psychopharmacology, 1, 87–102.

    Article  PubMed  Google Scholar 

  • Hunt, R. D., Mandl, L., Lau, S., & Hughes, M. (1991). Neurobiological theories of ADHD and ritalin. In L. L. Greenhill & B. Osman (Eds.), Ritalin: Theory and patient management (pp. 267–288). New York: Liebert.

    Google Scholar 

  • Hunt, R. D., Arnsten., A., & Asbell, M. D. (1995). An open trial of guanfacine in the treatment of attention deficit hyperactivity disorder in boys. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 50–54.

    Article  PubMed  Google Scholar 

  • Kafantaris, V., Campbell, M., Padron-Gayol, M. V., Small, A. M., Locascio, J. J., & Rosenberg, C. R. (1992). Carbamazepine in hospitalized aggressive conduct disorder children: An open pilot study. Psychopharmacology Bulletin,28, 193–199.

    PubMed  Google Scholar 

  • Kaplan, S. L., Busner, J., Kupietz, S., Wassermann, E., & Segal, B. (1990). Effects of methylphenidate on adolescents with aggressive conduct disorder and ADDH: A preliminary report. Journal of the American Academy of Child and Adolescent Psychiatry,29, 719–723.

    Article  PubMed  Google Scholar 

  • Kastner, T., Finesmith, R., & Walsh, K. (1993). Longterm administration of valproic acid in the treatment of affective symptoms in people with mental retardation. Journal of Clinical Psychopharmacology, 13, 448–451.

    Article  PubMed  Google Scholar 

  • Klein, R. G., Abikoff, H., Klass, E., Ganeles, D., Seese, L. M., & Pollack, S. (1997). Clinical efficacy of methyl-phenidate in conduct disorder with and without ADHD. Archives of General Psychiatry, 54, 1073–1080.

    Article  PubMed  Google Scholar 

  • Kostowski W., Valzelli, L., Kozak, W., & Bernasconi, S. (1984) Activity of desipramine, fluoxetine and nomifensine on spontaneous and p-CPA-induced muricidal aggression. Pharmacological Research Communications, 16, 265–271.

    Article  PubMed  Google Scholar 

  • Kulkarni, A. S., & Plotnikoff, N. P. (1978). Effects of stimulants on aggressive behavior. Modern Problems of Pharmacopsychiatry, 13, 69–81.

    PubMed  Google Scholar 

  • Maj, J., Mogilnicka, E., & Kordecka-Magiera, A. (1979). Chronic treatment with antidepressant drugs: Potentiation of apomorphine-induced aggressive behaviour in rats. Neuroscience Letters, 13, 337–341.

    Article  PubMed  Google Scholar 

  • Maj, J., Mogilnicka, E., & Kordecka-Magiera, A. (1980). Effects of chronic administration of antidepressant drugs on aggressive behavior induced by clonidine in mice. Pharmacology, Biochemistry and Behavior, 13, 153–154.

    Article  Google Scholar 

  • Malick, J. G. (1978). Inhibition of fighting in isolated mice following repeated administration of lithium chloride. Pharmacology, Biochemistry and Behavior, 8, 579–581.

    Article  Google Scholar 

  • Malone, R. P., Luebbert, J., Pena-Ariet, M., Biesecker, K., & Delaney, M. A. (1994). The Overt Aggression Scale in a study of lithium in aggressive conduct disorder. Psychopharmacology Bulletin,30,215–218.

    PubMed  Google Scholar 

  • Mann, J. J. (1995). Violence and aggression. In F. E. Bloom & D. Kupfer (Eds.), Psychopharmacology: The fourth generation of progress (pp. 1919–1928). New York: Raven.

    Google Scholar 

  • Markowitz, P. I. (1992). Effect of fluoxetine on self-injurious behavior in the developmentally disabled: A preliminary study. Journal of Clinical Psychopharmacology, 2, 27–31.

    Google Scholar 

  • Matsumoto, K., Cai, B., Satoh, T., Ohta, H., & Watanabe, H. (1991). Desipramine enhances isolation-induced aggressive behavior in mice. Pharmacology, Biochemistry and Behavior,39,167–170.

    Article  Google Scholar 

  • Matsumoto, K., Ojima, K., & Watanabe, H. (1995) Noradrenergic denervation attenuates desipramine enhancement of aggressive behavior in isolated mice. Pharmacology, Biochemistry and Behavior, 50, 481–484.

    Article  Google Scholar 

  • Miczek, K. A., & Barry, H. (1977). Comparison of the effects of alcohol, chlordiazepoxide, and delta 9-tetrahydrocannabinol on intraspecies aggression in rats. Advances in Experimental Medicine and Biology, 85B, 251–264.

    Article  PubMed  Google Scholar 

  • Miczek, K. A., & O’Donnell, J. M. (1978). Intruder-evoked aggression in isolated and nonisolated mice: Effects of psychomotor stimulants and L-dopa. Psychopharmacology,57,47–55.

    Article  PubMed  Google Scholar 

  • Millman, R. B., & Beeder, A. B. (1994). Cannabis. In M. Galanter & H. D. Kleber (Eds.). Textbook of substance abuse treatment (pp. 99–110). Washington, DC: American Psychiatric Press.

    Google Scholar 

  • Moyer, K. E. (1968). Kinds of aggression and their physiological basis. Communications in Behavioral Biology, 2, 65–87.

    Google Scholar 

  • Myerscough, R., & Taylor, S. (1985). The effects of marijuana on human physical aggression. Journal of Personality and Social Psychology,49,1541–1546.

    Article  PubMed  Google Scholar 

  • Ockene, J. K., & Kristeller, J. L. (1994). Tobacco. In M. Galanter & H. D. Kleber (Eds.), Textbook of substance abuse treatment (pp. 157–178). Washington, DC: American Psychiatric Press.

    Google Scholar 

  • Okuma, T., Yamashita, I., Takahashi, R., Itoh, H., Otsuki, S., Watanabe, S., Sarai, K., Hazama, H., & Inanaga, K. (1989). A double-blind study of adjunctive carbamazepine versus placebo on excited states of schizophrenic and schizoaffective disorders. Acta Psychiatrica Scandinavica, 80, 250–259.

    Article  PubMed  Google Scholar 

  • Olivier, B., Mos, J., van Oorschot, R., & Hen, R. (1995). Serotonin receptors and animal models of aggressive behavior. Pharmacopsychiatry, 28 (Suppl. 2), 80–90.

    Article  PubMed  Google Scholar 

  • Patterson, J. F. (1988). A preliminary study of carbamazepine in the treatment of assaultive patients with dementia. Journal of Geriatric Psychiatry and Neurology, 1, 21–23.

    Article  PubMed  Google Scholar 

  • Quay, H. C. (1993). The psychobiology of undersocialized aggressive conduct disorder: A theoretical perspective. Development and Psychopathology,5,165–180.

    Article  Google Scholar 

  • Quay, H. C. (1997). Inhibition and Attention Deficit Hyperactivity Disorder. Journal of Abnormal Child Psychology, 25, 7–13.

    Article  PubMed  Google Scholar 

  • Raleigh, M. J., McGuire, M. T., Brummer, G. L., Pollack, D. B., & Yuwiler, A. (1991). Serotonergic mechanisms promote dominance acquisition in adult male vervet monkeys. Brain Research, 559, 181–190.

    Article  PubMed  Google Scholar 

  • Rall, T. W., Nies, A. S., & Taylor, P. (1991). Goodman and Gilman’s The pharmacological basis of therapeutics (8th ed.). New York: Maxwell McMillan.

    Google Scholar 

  • Rapport, M. D., Sonis, W. A., Fialkov, M. J., Matson, J. L., & Kazdin, A. E. (1983). Carbamazepine and behavior therapy for aggressive behavior: Treatment of a mentally retarded, postencephalitic adolescent with seizure disorder. Behavior Modification, 7, 255–265.

    Article  PubMed  Google Scholar 

  • Reis, D. (1971). Brain monoamines in aggression and sleep. Clinical Neurosurgery, 18, 471–502.

    PubMed  Google Scholar 

  • Reis, D. (1974). Central neurotransmitters in aggression. Research Publications of the Association for Research in Nervous and Mental Disease, 52, 119–148.

    Google Scholar 

  • Reiss, S., & Aman, M. G. (Eds.). (1998). Psychotropic drugs and developmental disabilities: The international consensus handbook. Columbus, OH: Nisonger Center.

    Google Scholar 

  • Schroeder, S. R. (1988). Neuroleptic drugs for persons with developmental disabilities. In M. G. Aman & N. N. Singh (Eds.), Psychopharmacology of the developmental disabilities (pp. 82–100). New York: Springer-Verlag.

    Chapter  Google Scholar 

  • Sheard, M. H., Marini, J. L., Bridges, C. I., & Wagner, E. (1976). The effect of lithium on impulsive aggressive behavior in man. American Journal of Psychiatry, 133, 1409–1413.

    PubMed  Google Scholar 

  • Spreat, S., Behar, D., Reneski, B., & Miazzo, P. (1989). Lithium carbonate for aggression in mentally retarded persons. Comprehensive Psychiatry, 30, 505–511.

    Article  PubMed  Google Scholar 

  • Stoewe, J. K., Kruesi, M. J. P., & Lelio, D. F. (1995). Pharmacotherapy of aggressive states and features of conduct disorder. Child and Adolescent Psychiatric Clinics of North America,4,359–380.

    Google Scholar 

  • Stringer, A. Y, & Josef, N. C. (1983). Methylphenidate in the treatment of aggression in two patients with antisocial personality disorder. American Journal of Psychiatry, 140, 1365–1366.

    PubMed  Google Scholar 

  • Troisi, A., Vicario, E., Nuccetelli, F., Ciani, N., & Pasini, A. (1995). Effects of fluoxetine on aggressive behavior of adult inpatients with mental retardation and epilepsy. Pharmacopsychiatry,28,73–76.

    Article  PubMed  Google Scholar 

  • Vitiello, B., Behar, D., Hunt, J., Stoff, D., & Ricciuti, A. (1990). Subtyping aggression in children and adolescents. Journal of Neuropsychiatry, 2, 189–192.

    Google Scholar 

  • Werry, J. S. (1994). Pharmacotherapy of disruptive behavior disorders. Child and Adolescent Psychiatric Clinics of North America, 3, 321–342.

    Google Scholar 

  • Werry, J. S., & Aman, M. G. (1998). Anxiolytic and miscellaneous drugs. In J. S. Werry & M. G. Aman (Eds.), A practitioner’s guide to psychoactive drugs for children and adolescents (2nd ed., pp. 433–470). New York: Plenum.

    Google Scholar 

  • Whitaker, A., & Rao, U. (1992). Neuroleptics in pediatric psychiatry. Psychiatric Clinics of North America, 15, 243–276.

    PubMed  Google Scholar 

  • Whitman, S., Benbow, N., & Good, G. (1996). The epidemiology of homicide in Chicago. Journal of the National Medical Association, 88, 781–787.

    PubMed  Google Scholar 

  • Yamaguchi, K., & Kandel, D. B. (1984). Patterns of drug use from adolescence to young adulthood: II. Sequences of progression. American Journal of Public Health, 74, 668–672.

    Article  PubMed  Google Scholar 

  • Yassa, R., & Dupont, D. (1983). Carbamazepine in the treatment of aggressive behavior in schizophrenic patients: A case report. Canadian Journal of Psychiatry,28,566–568.

    Google Scholar 

  • Yatham, L. N., & McHale, P. A. (1988). Carbamazepine in the treatment of aggression: A case report and a review of the literature. Acta Psychiatrica Scandinavica, 78, 188–190.

    Article  PubMed  Google Scholar 

  • Yoshikawa, H. (1994). Prevention as cumulative protection: Effects of early family support and education on chronic delinquency and its risks. Psychological Bulletin, 115, 28–54.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Child Psychiatry, New York State Psychiatric Institute/Columbia University, New York, New York, 10032, USA

    Bruce Waslick & Laurence L. Greenhill

  2. Department of Psychiatry, University of Auckland, Auckland, New Zealand

    John S. Werry

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  1. University of Miami, Coral Gables, Florida, USA

    Herbert C. Quay  & Anne E. Hogan  & 

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Waslick, B., Werry, J.S., Greenhill, L.L. (1999). Pharmacotherapy and Toxicology of Oppositional Defiant Disorder and Conduct Disorder. In: Quay, H.C., Hogan, A.E. (eds) Handbook of Disruptive Behavior Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4881-2_21

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