Does Psychological Depression Cause Immune Suppression in Humans?

  • Michael Irwin
  • Elliot Friedman


Considerable evidence suggests that major depression places people at increased risk for physical morbidity and mortality. The mechanisms responsible for the decline of well-being in persons with major depression are not known, but recent research has hypothesized that immune alterations might be one pathway through which depression influences physical health. However, disparate results have been obtained in the study of immune function in depressed patients, and a general consensus that depression is associated with immune alterations has not been reached.


Depressive Symptom Depressed Patient Life Stress Sleep Deprivation Total Sleep Time 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Michael Irwin
    • 1
  • Elliot Friedman
    • 2
  1. 1.Departments of PsychiatrySan Diego VA Medical Center and University of CaliforniaSan DiegoUSA
  2. 2.Department of PsychologyWilliams CollegeWilliamstownUSA

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