Abstract
In response to arginine vasopressin (AVP) concentrated urine is produced by water reabsorption across renal collecting duct cells (1). Sasaki et al (2,3) recently cloned a cDNA of apical collecting duct water channel, aquaporin-2 (AQP-2) of the rat and human kidney. AQP-2 are present in the membrane of cytoplasmic vesicles of collecting duct cells, and are translocated to the apical membrane when the cells are stimulated by AVP (4–7). These findings are predicted by “the shuttle hypothesis” and indicate that AQP-2 is the AVP-regulated water channel of the collecting duct cells. There are two types of regulation of AQP-2 gene expression by AVP, namely a prompt alteration in AQP-2 as described above, and a sustained expression of AQP-2.
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Ishikawa, Se., Saito, T., Sasaki, S., Saito, T. (1998). Prompt and Sustained Regulation of Aquaporin-2 by Arginine Vasopressin in Collecting Duct Cells and Clinical Implication of Urinary Excretion of Aquaporin-2. In: Zingg, H.H., Bourque, C.W., Bichet, D.G. (eds) Vasopressin and Oxytocin. Advances in Experimental Medicine and Biology, vol 449. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4871-3_52
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DOI: https://doi.org/10.1007/978-1-4615-4871-3_52
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