Abstract
The thymus is the primary lymphoid organ responsible for the positive and negative selection of the peripheral T-cell repertoire. Specific neuroendocrine-immune interactions were shown to take place in the thymic microenvironnement. Two distinct types of cell-tocell signaling are mediated by thymic neuroendocrine-related peptides and might partially explain the dual physiological role of the thymus in T-cell differentiation (1–3). Thymic epithelial cells (TEC) from different species express a repertoire of proteins belonging to various neuroendocrine families. Prooxyphysin is the dominant thymic precursor of the neurohypophysial family, and proinsulin-like growth factor-II is the dominant thymic insulin-related polypeptide.
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References
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© 1998 Springer Science+Business Media New York
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Martens, H., Kecha, O., Charlet-Renard, C., Defresne, MP., Geenen, V. (1998). Phosphorylation of Proteins Induced in a Murine Pre-T Cell Line by Neurohypophysial Peptides. In: Zingg, H.H., Bourque, C.W., Bichet, D.G. (eds) Vasopressin and Oxytocin. Advances in Experimental Medicine and Biology, vol 449. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4871-3_33
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DOI: https://doi.org/10.1007/978-1-4615-4871-3_33
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