Abstract
It is important to realize that neuropeptides such as vasopressin (AVP) and oxytocin (OXT) only become biologically active after their release into the extracellular space. To measure this release, the majority of previous studies have relied on post-mortem methods, which only offer limited snapshots at selected time frames in a dynamic process. Thus, although measurements of AVP and OXT content in brain tissue, of neuropeptide concentrations in the cerebrospinal fluid and attempts to reflect central fluctuations in AVP and OXT just by determining plasma peptide levels have all substantially contributed to our present knowledge, they have to be interpreted with extreme caution.
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Engelmann, M., Wotjak, C.T., Landgraf, R. (1998). Differential Central and Peripheral Release of Vasopressin and Oxytocin in Response to Swim Stress in Rats. In: Zingg, H.H., Bourque, C.W., Bichet, D.G. (eds) Vasopressin and Oxytocin. Advances in Experimental Medicine and Biology, vol 449. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4871-3_20
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DOI: https://doi.org/10.1007/978-1-4615-4871-3_20
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