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Vasopressin Receptors

A Historical Survey

  • Chapter
Vasopressin and Oxytocin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 449))

Abstract

In 1895, the discovery by Oliver and Schäfer1 of the mammalian pressor effect of beef pituitary extracts constituted the starting point of more than a century of active research on the structure and function of vertebrate neurohypophysial principles. During the two decades following Oliver and Schäfer’s discovery, the main biological effects of neurohypophysial extracts were described, namely oxytocic2, milk-ejecting3, avian depressor4 and antidiuretic5 activities. Efficient and well standardized bioassay procedures were derived from these initial discoveries, the first of which was the guinea-pig uterus assay introduced by Dale and Laidlaw in 19126. It was not until 1949, however, that oxytocin was isolated in a highly purified form.

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  1. Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France

    Serge Jard

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  1. McGill University, Montreal, Quebec, Canada

    Hans H. Zingg  & Charles W. Bourque  & 

  2. University of Montreal, Montreal, Quebec, Canada

    Daniel G. Bichet

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Jard, S. (1998). Vasopressin Receptors. In: Zingg, H.H., Bourque, C.W., Bichet, D.G. (eds) Vasopressin and Oxytocin. Advances in Experimental Medicine and Biology, vol 449. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4871-3_1

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