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Cell Culture Models of Neuronal Degeneration and Neuroprotection

Implications for Parkinson’s Disease

  • Chapter
Molecular and Cellular Mechanisms of Neuronal Plasticity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 446))

Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra (McGeer, et al., 1988). The disease has a late onset, and is fairly prevalent, affecting 1% of the general population over the age of 50 (Polymeropoulos, et al., 1996). Treatment for the disorder is largely symptomatic, usually beginning with dopaminergic agonist therapy, or with a combination of levo-dopa (L-DOPA) and dopaminergic receptor agonists (see Rabey, 1995 and Corboy et al., 1995 for review).

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Authors and Affiliations

  1. Department of Neurology, Mount Sinai School of Medicine, New York, New York, 10029, USA

    Efthimia T. Kokotos Leonardi & Catherine Mytilineou

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  1. Efthimia T. Kokotos Leonardi
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  2. Catherine Mytilineou
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  1. The College of Staten Island of The City University of New York, USA

    Yigal H. Ehrlich

  2. The CSI/IBR Center for Developmental Neuroscience Staten Island, New York, USA

    Yigal H. Ehrlich

  3. The City University Graduate School, New York, New York, USA

    Yigal H. Ehrlich

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Kokotos Leonardi, E.T., Mytilineou, C. (1998). Cell Culture Models of Neuronal Degeneration and Neuroprotection. In: Ehrlich, Y.H. (eds) Molecular and Cellular Mechanisms of Neuronal Plasticity. Advances in Experimental Medicine and Biology, vol 446. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4869-0_12

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