Abstract
Processes like angiogenesis are critically dependent on local oxygen supply. It is known that hypoxia induces an up-regulation of the vascular endothelial growth factor (VEGF, Giaccia et al. 1995, Goldberg and Schneider 1994, Hlatky et al. 1995, Shweiki et al. 1992) gene, increased synthesis of the peptide and an increased proliferation of endothelial cells. Also tumour growth is associated with angiogenesis (Bikfalvi 1995) and it has been shown that different tumour cells increase the VEGF production during hypoxia.
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Literature
Bikfalvi, A. Significance of angiogenesis in tumour progression and metastasis. Eur J Cancer 31, 1101–1104 (1995).
Dümmler, W. Bestimmung von Hämoglobin-Oxygenierung und relativer Hämoglobin-Konzentration in biologischen Systemen durch Anwendung der Kubelka-Munk-Theorei, Thesis, Erlangen 1988.
Frank, KH, Kessler, M, Appelbaum, K, Dümmler, W. The Erlangen micro-lightguide spectrophotometer EMPHO I. Phys Med Biol 34, 1883–1900 (1989).
Giaccia, AJ, Chen, EY, Yeh, P, Waleh, N, Laderoute, KR., Mazure, NM. Regulation of vascular endothelial growth factor by hypoxia. Proc. 10th Int. Congress of Radiation Research (abstract PI 1-11) p 218, Wuerzburg, Germany 1995.
Goldberg, MA, Schneider, TJ. Similarities between the oxygen sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J Biol Chem 269, 4355–4359 (1994).
Hlatky, L, Tsionou, C, Hahnfeldt, P, Coleman, N. VEGF expression in human mammary tumor cells: Upregulation with hypoxia. Proc. 10th Int. Congress of Radiation Research (abstract PI 1-12) p 218, Wuerzburg, Germany 1995.
Höper, J, Jahn, H. Influence of environmental oxygen concentration on growth and vascular density of the area vasculosa in chick embryos. Int J Microcirc 15, 186–192 (1995).
Höper, J, Funk, RHW. A combination of microendoscopy and spectrophotometry allowing real-time analysis of microcirculatory parameters during in vivo observations. Physiol Meas 15, 333–337 (1994).
Höper, J, Plasswilm, L. Micro-light guide spectrophotometric measurement of changes in local haemoglobin oxygenation and concentration in the rabbit lung induced by hypoxia and hyperoxia. Int J Microcirc 14, 282–288(1994).
Kubelka, P, Munk, F. Ein Beitrag zur Optik der Farbanstriche. Z Tech Physik, lla, 76–77, 1931.
Mitchell, CR, Sorenson, JA. Digital image processing in chest radiography. In: Application of Optical Instrumentation in Medicine XIV: Medical Imaging, Processing, Display and Picture Archiving and Communication Systems (PACS IV) for Medical Applications. Eds.: R. Schneider, H. Dwyer, SJ Bellingham. Proc SPIE 626,259–264(1986).
Pfluger, T, Reinfelder, K. Gegenüberstellung verschiedener Filtermethoden bei der digitalen Verarbeitung von Röntgenbildern. Electromedica 55, 78–87 (1987).
Shweiki, D, Itin, A, Soffer, D, Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 39, 843–845 (1992).
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Böhnert, M., Höper, J. (1998). Simultaneous in Vivo Investigation of Structural and Functional Parameters in a Growing Vascular System. In: Hudetz, A.G., Bruley, D.F. (eds) Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology, vol 454. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4863-8_39
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DOI: https://doi.org/10.1007/978-1-4615-4863-8_39
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