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Oxygen Transport to Tissue XX pp 325–333Cite as

Chronic Radiation Bone Toxicity is Associated with Decreased Perfusion Without Elevation of Circulating or Soft Tissue TGFβ or TNFα

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 454))

Abstract

Concern over long term bone growth hampers the full utility of radiation in pediatric oncology. We know of no therapies that have been used routinely as prophylaxis following irradiation to prevent complications of bone, though some have been suggested.23 Radiation is known to have severe and prolonged anti-angiogenic and fibrogenic effects.20,21,29,30 These effects are species and strain dependent in experimental animals.15 Though the mechanism of this anti-angiogenic response is unknown, it is likely that a component of this effect is cytokine mediated.2,15 In previous studies we have found that angiogenic factors can alleviate some acute complications of radiotherapy. We hypothesize that angiogenic therapies featuring cytokines or cytokine modifying agents can also prevent or reduce some late complications. To test this hypothesis we electively treated mice with basic fibroblast growth factor (bFGF) up to 2 months after irradiating a single hind leg and then measured tibia growth, circulating and local tissue anti-angiogenic cytokine production, and tibia bone blood flow

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642, USA

    Paul Okunieff, Ming Li, Jacqueline Williams, Philip Rubin & Ivan Ding

  2. Radiation Oncology Branch Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland, 20892, USA

    Xin Wang, Hjeer Sabet, Kundi Huang & J. Robert Grieg

Authors
  1. Paul Okunieff
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  2. Xin Wang
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  3. Ming Li
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  4. Hjeer Sabet
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  5. Kundi Huang
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  6. J. Robert Grieg
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  7. Jacqueline Williams
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  8. Philip Rubin
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  9. Ivan Ding
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Editor information

Editors and Affiliations

  1. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Antal G. Hudetz

  2. University of Maryland, Baltimore County, Baltimore, Maryland, USA

    Duane F. Bruley

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© 1998 Springer Science+Business Media New York

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Okunieff, P. et al. (1998). Chronic Radiation Bone Toxicity is Associated with Decreased Perfusion Without Elevation of Circulating or Soft Tissue TGFβ or TNFα. In: Hudetz, A.G., Bruley, D.F. (eds) Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology, vol 454. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4863-8_38

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  • DOI: https://doi.org/10.1007/978-1-4615-4863-8_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7206-6

  • Online ISBN: 978-1-4615-4863-8

  • eBook Packages: Springer Book Archive

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