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Adaptation of Hearts to Chronic Hypoxia Increases Tolerance to Subsequent Ischemia by Increased Nitric Oxide Production

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Oxygen Transport to Tissue XX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 454))

Abstract

Each year, in excess of 25,000 children undergo corrective surgery for cardiac birth defects. Advances in surgical techniques have made possible the correction of nearly all congenital cardiac defects. Timing of surgery is critically important, with early surgery desirable to promote more normal development. For example, repair of tetralogy of Fallot is now generally recommended in the first 6 to 12 months of life, and routine repair is now being advocated in the first month of life.1–7 Many children undergoing cardiac surgery in the first year of life exhibit varying degrees of cyanotic heart disease where the myocardium is chronically perfused with hypoxic blood. Understanding the mechanisms by which cyanotic congenital heart disease modifies the myocardium and how that modification impacts on protective mechanics during ischemia may provide insight into developing treatments for limiting myocardial damage during surgery.

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Author information

Authors and Affiliations

  1. Department of Cardiothoracic Surgery, Medical College of Wisconsin, 9200 W. Wisconsin Ave., 53226, USA

    John E. Baker & Patricia Holman

  2. Department of Cardiovascular Surgery, Children’s Hospital of Wisconsin, 9000 W. Wisconsin Ave., Milwaukee, Wisconsin, 53226, USA

    John E. Baker

  3. Biophysics Institute, Medical College of Wisconsin, 9200 W. Wisconsin Ave., 53226, USA

    B. Kalyanaraman

  4. Department of Pathology, Medical College of Wisconsin, 9200 W. Wisconsin Ave., 53226, USA

    Kirkwood A. Pritchard Jr.

Authors
  1. John E. Baker
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  2. Patricia Holman
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  3. B. Kalyanaraman
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  4. Kirkwood A. Pritchard Jr.
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Editor information

Editors and Affiliations

  1. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Antal G. Hudetz

  2. University of Maryland, Baltimore County, Baltimore, Maryland, USA

    Duane F. Bruley

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© 1998 Springer Science+Business Media New York

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Baker, J.E., Holman, P., Kalyanaraman, B., Pritchard, K.A. (1998). Adaptation of Hearts to Chronic Hypoxia Increases Tolerance to Subsequent Ischemia by Increased Nitric Oxide Production. In: Hudetz, A.G., Bruley, D.F. (eds) Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology, vol 454. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4863-8_25

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  • DOI: https://doi.org/10.1007/978-1-4615-4863-8_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7206-6

  • Online ISBN: 978-1-4615-4863-8

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