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Bold MRI vs. NIR Spectrophotometry

Will the Best Technique Come Forward?

  • Chapter
Oxygen Transport to Tissue XX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 454))

Abstract

This paper will discuss the assumptions, strengths and weaknesses of both BOLD imaging and NIR spectrophotometry with respect to monitoring tissue oxygenation. BOLD, or blood oxygen level dependent MRI, is an imaging protocol that is sensitive to specific relaxation rates which are influenced by deoxyhemoglobin. NIRS is capable of providing information on oxyhemoglobin, deoxyhemoglobin and total hemoglobin. Both techniques have inherent assumptions, strengths and weaknesses. NIRS has not been able to provide the spatial sensitivity of BOLD. BOLD may be more difficult to quantify. Currently, these two methods are complementary, providing data that strengthens the interpretation of results from each modality. Recent data indicate that relaxation rates can be used to quantify deoxyhemoglobin in isolated blood and, under specific conditions, there is a strong correlation between deoxyhemoglobin content measured by NIRS and changes in relaxation rates measured by MRI. These data indicate that BOLD imaging has the potential to become an attractive alternative to NIRS.

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Author information

Authors and Affiliations

  1. Biomedical NMR Research Laboratory Department of Diagnostic Radiology, Dartmouth Medical School, USA

    Jeff F. Dunn & Youssef Zaim-Wadghiri

  2. Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA

    Brian W. Pogue

  3. Biophysics Laboratory Research Institute for Electronic Science, Hokkaido University, Japan

    Ikuhiro Kida

Authors
  1. Jeff F. Dunn
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  2. Youssef Zaim-Wadghiri
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  3. Brian W. Pogue
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  4. Ikuhiro Kida
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Editor information

Editors and Affiliations

  1. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Antal G. Hudetz

  2. University of Maryland, Baltimore County, Baltimore, Maryland, USA

    Duane F. Bruley

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© 1998 Springer Science+Business Media New York

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Dunn, J.F., Zaim-Wadghiri, Y., Pogue, B.W., Kida, I. (1998). Bold MRI vs. NIR Spectrophotometry. In: Hudetz, A.G., Bruley, D.F. (eds) Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology, vol 454. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4863-8_13

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  • DOI: https://doi.org/10.1007/978-1-4615-4863-8_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7206-6

  • Online ISBN: 978-1-4615-4863-8

  • eBook Packages: Springer Book Archive

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