Metal Regulation of Metallothionein Gene Transcription in Mammals

  • P. Remondelli
  • O. Moltedo
  • M. C. Pascale
  • Arturo Leone
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 448)


Heavy metals play their essential role as nutrients and as cofactors for a variety of enzymes and metallo-proteins (O’Halloran, 1989). Metals are normally present in trace amount in the cell but these levels can increase consistently following environmental or nutritional changes. To avoid toxic effects and death due to metal overload, cells have de-veloped during evolution several biochemical and molecular mechanisms which regulate the metal uptake, its intracellular distribution and elimination from the intracellular compartments. Therefore, it appears that two main processes control intracellular metal ho-meostasis, the first based on the regulation of the enzymatic activities of metal pumps and transporters, the second activating gene transcription.


Candida Glabrata Metal Regulation Intracellular Metal Metal Response Element Metal Induction 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • P. Remondelli
    • 1
  • O. Moltedo
    • 1
  • M. C. Pascale
    • 2
  • Arturo Leone
    • 2
  1. 1.Dipartimento di Biochimica e Biotecnologie MedicheUniversitè degli Studi di Napoli “Federico II”Italy
  2. 2.Dipartimento di Scienze FarmaceuticheUniversité degli Studi di SalernoPenta di Fisciano (Salerno)Italy

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