The Effect of Copper on Tight Junctional Permeability in a Human Intestinal Cell Line (Caco-2)
Copper is a trace element essential to life, participating to a wide number of biochemical reactions as cofactor of many enzymes (Linder, 1991). However, it also exhibits toxic effects and can impair cellular functions (Goyer, 1994). For this reason it is crucial to understand the relashionship between requirements and toxicity of this heavy metal.
KeywordsTight Junction Transepithelial Electrical Resistance Human Intestinal Cell Plasma Membrane Domain Tight Junction Integrity
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