Localized Morphea in Children
We are following 60 patients with morphea and/or linear scleroderma at the Hospital for Sick Children, Toronto. Lesions may vary in depth from epidermal changes resembling lichen sclerosis, to superficial and deep dermal changes. The subcutaneous tissue, bone and muscle may be involved. There is no good clinical marker of the disease. Because of the variation in the time to cure, it is difficult to evaluate treatment regimens. We are currently using methotrexate weekly either orally or subcutaneously and monthly pulsed steroids for three months.
KeywordsBorrelia Burgdorferi Lichen Sclerosus Progressive Systemic Sclerosis Porphyria Cutanea Tarda Poem Syndrome
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- 3.Jablonska S: Scleroderma and pseudoscleroderma. 2nd Ed. Warsaw Poland: Polish Medical Publishers, pgs 537–546. 1975.Google Scholar
- 6.Meis JF, Koopman R, van Bergen B, Pool G, Melchers W: No evidence for a relation between Borrelia burgdorferi infection and old lesions of localized scleroderma (morphea). Letter to Editor. Arch Dermatol. 129: 386–387. 1993.Google Scholar
- 10.Birdi N, Laxer RM, Thorner P, Fritzler MJ, Silverman ED: Localized scleroderma progressing to systemic disease. Case report and review of the literature. Arthritis Rheum. 36(3): 410–415. 1993.Google Scholar
- 11.Uziel Y, Krafchik BR, Feldman B, Silverman ED, Rubin LA, Laxer RM: Serum levels of soluble inter-leukin-2 receptor. A marker of disease activity in localized scleroderma. Arthritis Rheum. 37(6): 898–901. 1994.Google Scholar