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Chondrocytes-ECM Interactions in Human Osteoarthritis

  • Chapter
Rheumaderm

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 455))

Abstract

Interactions between cells and extracellular matrix (ECM) are critical to the biological processes that take place in tissue such as cartilage. These processes include cell adhesion, growth, differentiation, migration, and matrix synthesis and degradation. The cell receptors playing a central role in cellular attachment to ECM are members of integrin family of heterodimeric transmembrane glycoproteins and some other cell membrane proteins: recently we have demonstrated that the cell membrane-bound peptidases CD 10 and CD26 are expressed on human articular chondrocytes and that their expression decreases with the worsening of osteoarthritis. Unpublished observations about the intracellular levels of substance P, met-Enkephalin, GRP and IL 10, carried out in our lab, seem to confirm the hypothesis that the “inside-out signaling” mediated by adhesion molecules, cooperates with a network of growth factors and cytokines, locally produced and carried through the ECM.

Our studies provide evidence that chondrocytes are supplied with an ample system of receptors widely interacting with an environmental signaling system and with the ECM that may act as “solid state modulator” of their metabolic activity. Final result of these interactions is the homeostatic balance or, alternatively, in case of disturbing circumstances, the metabolic alteration heading to the typical changes of osteoarthritis.

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Authors and Affiliations

  1. Rheumatology Unit Department of Internal Medicine and Occupational Health, University of Bari, Italy

    Prof. Giovanni Lapadula (Associate Professor of Rheumatology) & Florenzo Iannone (Research Assistant in Rheumatology)

Authors
  1. Prof. Giovanni Lapadula
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  2. Florenzo Iannone
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Correspondence to Giovanni Lapadula .

Editor information

Editors and Affiliations

  1. St. Luke’s Hospital, University of Malta Medical School, Malta, USA

    Carmel Mallia

  2. Jefferson Medical College, Thomas Jefferson Universit, Philadelphia, Pennsylvania, USA

    Jouni Uitto

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© 1999 Springer Science+Business Media New York

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Lapadula, G., Iannone, F. (1999). Chondrocytes-ECM Interactions in Human Osteoarthritis. In: Mallia, C., Uitto, J. (eds) Rheumaderm. Advances in Experimental Medicine and Biology, vol 455. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4857-7_62

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  • DOI: https://doi.org/10.1007/978-1-4615-4857-7_62

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7203-5

  • Online ISBN: 978-1-4615-4857-7

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