Rheumaderm pp 35-48 | Cite as

Scleroderma in Children

  • C. M. Black
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 455)


Scleroderma is not one disease but a spectrum of disorders that can occur at any time of life, although the pattern of scleroderma occurring in children is different from that in adults. Fortunately, the predominant form of disease in childhood is localised scleroderma, which includes morphoea and linear scleroderma with the en coup de sabre subset [1,2].


Interstitial Lung Disease Systemic Sclerosis Alopecia Areata Mixed Connective Tissue Disease Localise Scleroderma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Falanga V: Localised scleroderma. Med Clin North Am; 73: 1143–1156. 1989PubMedGoogle Scholar
  2. 2.
    Jablonska S: Scleroderma andPseudo-scleroderma. Warsaw: Warsaw Polish Medical Publishers: 1975.Google Scholar
  3. 3.
    Black CM: Prognosis and management of scleroderma and scleoderma-like disorders in children [review]. Clin Exp Rheumatol; 12(suppl 10): S75–81. 1994Google Scholar
  4. 4.
    Ansell BM, Falcini F, Woo P: Scleroderma in childhood, Clin Dermatol; 12: 229–307. 1994CrossRefGoogle Scholar
  5. 5.
    Dabich L, Sullivan DB, Cassidy JT: Scleroderma in the child. J Pediatr; 85: 770–775. 1974PubMedCrossRefGoogle Scholar
  6. 6.
    Hanson V: Dermatomyositis, scleroderma and polyarteritis nodosa. Clin Rheum Dis; 2: 445–467. 1976Google Scholar
  7. 7.
    Dabich L: Scleroderma. In Texbook of Paediatric Rehumatology, Edited by Cassidy JT, New York: Wiley:. 433–471. 1982Google Scholar
  8. 8.
    Lehman TJA: The Parry Romberg syndrome of progressive facial hemiatrophy and linear scleroderma en coup de sabre: mistaken diagnosis or overlapping conditions? [editorial]. J Rheumatol; 19: 844–845. 1992PubMedGoogle Scholar
  9. 9.
    Peterson LS, Nelson AM, Su WP, Mason T, O’Fallon WM, Gabriel SE: The epidermiology of morphoea (localised scleroderma in Olmsted County 1960–1993) J Rheumatol; 24: 73–80. 1997PubMedGoogle Scholar
  10. 10.
    Spiere Z, The B, Pick LA, Yamon M: Localised scleroderma following varicella in a three year old girl with IgA deficiency. Aca Paediatri Scand; 68: 783–785. 1979Google Scholar
  11. 11.
    Connelly MG, Winklemann RK: Co-existence of lichen sclerosis, morphoea and lichen plans. Report of four cases and review of the literature. J Am Acad Derm; 12; 844: 510. 1985Google Scholar
  12. 12.
    Peterson LS, Nelson AM, Su WP: Classification of morphoea Mayo Clinic Proc; 70: 1068–1076. 1995CrossRefGoogle Scholar
  13. 13.
    Diaz-Perez J L, Connelly SM, Winklemann RK: Disabling pausderthic morphoea in children Arch Derm; 116: 169–173. 1980PubMedCrossRefGoogle Scholar
  14. 14.
    Uziel Y, Krafchik BR, Silverman ED, Thorner PS, Laxer RM: Localised scleroderma in childhood: a report of 30 cases. Semin Arthritis Rheum; 23: 328–340. 1994PubMedCrossRefGoogle Scholar
  15. 15.
    Liu P, Uziel Y, Chuang S, Silverman E, Krafchik B, Laxer R; Localised scleroderma; imaging features. Pediatr Radiol; 24: 207–209. 1994PubMedCrossRefGoogle Scholar
  16. 16.
    Ansell BM, Nasseh GA, Bywaters EGL: Scleroderma in childhood. Ann Rheum Dis; 35: 189–197. 1976PubMedCrossRefGoogle Scholar
  17. 17.
    Allen RG, Ansell BM, Clark RP, Goff Mr, Waller R, Williamson S: Localised scleroderma: treatment of response measured by infra red thermography. Thermology; 2: 550–553. 1987Google Scholar
  18. 18.
    Birdi N, Shore A, Rush P, Laxer RM, Silverman ED, Krafchik B: Childhood linear scleroderma: a possible role of thermography for evaluation. J Rheumatol; 19: 968–973. 1992PubMedGoogle Scholar
  19. 19.
    Singsen BH: Scleroderma in childhood. Paediatr Clin North Am 33: 1119–1139. 1986Google Scholar
  20. 20.
    Ansell BM: Scleroderma in childhood. In Systemic Sclerosis: Scleroderma. Edited by Jayson MIV, Black CM. Chichester: Wiley; 319–320. 1988Google Scholar
  21. 21.
    Martinez-Cordero E, Fongech M, Aguliar Loon DE, Padilla A: Juvenile systemic sclerosis. J Rheumatol 20: 405–406. 1993PubMedGoogle Scholar
  22. 22.
    Bernstein RM, Pereira RS, Holdn AJ, Black CM, Howard A, Ansell BM: Antibodies in childhood scleroderma. Ann Rheum Dis; 44: 503–506. 1983CrossRefGoogle Scholar
  23. 23.
    Su’arez-Almazor MB, Catoggio LJ, Maldonado-Cocco JA, Cuttica R, Garciia-Morteo: Juvenile progressive systemic sclerosis: clinical and serological findings. Arthritis Rheum; 28: 699–702. 1985PubMedCrossRefGoogle Scholar
  24. 24.
    Pielte WW, Dorsey TK, Foncer E: Clinical and serological expression of localised SSc. J Am Acad Dermatol; 13: 342–350. 1985CrossRefGoogle Scholar
  25. 25.
    Falanga V, Medsger TA, Relchlin M: Antinuclear and anti-single stranded DNA antibodies in morphoea and generalised morphoea. Arch Dermatol; 123: 350–353. 1987PubMedCrossRefGoogle Scholar
  26. 26.
    Vancheeswaran R, Black CM, David J, Hasson N, Harper J, Atherton D, Trivedi P, Woo P. Childhood onset scleroderma — is it different from adult onset disease? Arthritis Rheum; 39(6): 1041–49. 1996PubMedCrossRefGoogle Scholar
  27. 27.
    Black CM: The aetiopathogenesis of systemic sclerosis: thick skin-thin hypotheses. The Parkes Weber Lecture. Journal of the Royal College of Physicians of London; 29(2): 119–130. 1995PubMedGoogle Scholar
  28. 28.
    Campbell PM and Le Roy: Pathogenesis of systemic sclerosis a vascular hypothesis. Sem Arthritis and Rheumatism; 4: 351–368. 1995CrossRefGoogle Scholar
  29. 29.
    Eckes B, Mauch C, Huppe G, Kreig T. Downregulation of collagen synthesis in fibroblasts within three dimensional collagen lattices involves transcriptional and post-transcriptional mechanisms. FEBS letters; 318: 129–133. 1993PubMedCrossRefGoogle Scholar
  30. 30.
    Pearson JD. The endothelium: Its role in systemic sclerosis. Ann Rheum Dis; 50: 866–871. 1990CrossRefGoogle Scholar
  31. 31.
    Kahaleh B, Matucci-Cerinic M. Raynaud’s phenomenon and scleroderma. Disregulation neuroendothelial control of vascular tone. Arthritis Rheum; 38: 1–4. 1995PubMedCrossRefGoogle Scholar
  32. 32.
    Prescot RJ, Freemont AJ, Jones CJ, Hoyland J and Fielding P. Sequential dermal microvascular and perivascular changes in the development of scleroderma. J Path; 166: 255–263. 1992CrossRefGoogle Scholar
  33. 33.
    Harrison NK, Myers AR, Corrin B, Sooray G et al. Structural features of interstitial lung disease in systemic sclerosis. Am Rev Resp Dis; 144: 706–713. 1991PubMedCrossRefGoogle Scholar
  34. 34.
    Blann AD, Illingworth K, Jayson Miv. Mechanisms of endothelial cell damage in systemic sclerosis and Raynaud’s phenomenon. J Rheumatol; 20: 1325–1330. 1993PubMedGoogle Scholar
  35. 35.
    Denton CP, Black CM. Systemic sclerosis in childhood. In Textbook of Paediatric Dermatology 1996; Editors Harper JI, Oranje AP, Prose NS.Google Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • C. M. Black
    • 1
  1. 1.Academic Unit of RheumatologyRoyal Free Hospital School of MedicineLondonUK

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