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Rheumaderm pp 285-288 | Cite as

Enalapril (10 Mg/Day) in Systemic Sclerosis

One Year, Double Blind, Randomised Study (ESS-1): ECG Exercise Testing—Three Months Follow-Up
  • Andrej BiłanEmail author
  • M. Chibowska
  • R. Palusiński
  • A. Witczak
  • S. Ostrowski
  • B. Makaruk
  • J. Węglarz
  • J. Hanzlik
  • D. Krasowska
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 455)

Abstract

The ESS-1 study was designed to evaluate the long-term effects of the angiotensin- converting enzyme inhibitor (ACEI) enalapril (10 mg per day) on cardiopulmonary system of patients with systemic sclerosis (SSc). Exercise testing is used not only for estimation of coronary reserve but also physical capacity—the major determinant of quality of life. In each patient included to the ESS-1 study we performed ECG exercise test on treadmill (5 times at intervals of 3 months).

The first follow-up was completed by 41 patients (23 patients in enalapril group and 18 in placebo group). The exercise duration in the placebo group was 683±295sec and in enalapril group 768±173sec. After 3 months of study there were no significant differences in both groups (758±271 sec and 720±191 sec respectively). The analysis of ST segment deviation did not provide any significant changes after 3 months of treatment. We conclude that 3 months enalapril treatment did not improve exercise tolerance in patients with systemic sclerosis.

Keywords

Systemic Sclerosis Physical Capacity Double Product Restrictive Lung Disease Undifferentiated Connective Tissue Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Andrej Biłan
    • 1
    Email author
  • M. Chibowska
    • 2
  • R. Palusiński
    • 1
  • A. Witczak
    • 1
  • S. Ostrowski
    • 1
  • B. Makaruk
    • 1
  • J. Węglarz
    • 1
  • J. Hanzlik
    • 1
  • D. Krasowska
    • 2
  1. 1.I Department of Internal MedicineUniversity School of MedicineLublinPoland
  2. 2.Department of DermatologyUniversity School of MedicineLublinPoland

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