Rheumaderm pp 227-233 | Cite as

Pyridinium Crosslinks Excretion in Patients with Rheumatoid Arthritis

Correlation with Disease Activity and Glucocorticoid Treatment
  • A. Xuereb Anastasi
  • A. Buhagiar
  • F. Camilleri
  • M. Cauchi
  • Carmel MalliaEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 455)


In patients with rheumatoid arthritis, significant positive correlations were found between urinary pyridinium crosslinks and C-reactive protein (CRJP), erythrocyte sedimentation rate (ESR) and articular index. Also an inverse correlation was observed between pyridinium crosslinks excretion and grip strength. Glucocorticoid therapy, equivalent to daily doses of 7.5mg of prednisolone or less, did not appear to have deleterious effect on bone metabolism in these patients as measured by urinary pyridinium crosslinks.


Rheumatoid Arthritis Bone Loss Erythrocyte Sedimentation Rate Grip Strength Glucocorticoid Therapy 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • A. Xuereb Anastasi
    • 2
  • A. Buhagiar
    • 3
  • F. Camilleri
    • 1
  • M. Cauchi
    • 2
  • Carmel Mallia
    • 1
    Email author
  1. 1.Department of MedicineUniversity of Malta Medical SchoolGuardamangia, MaltaUSA
  2. 2.Department of PathologyUniversity of Malta Medical SchoolGuardamangia, MaltaUSA
  3. 3.University of Malta Statistics UnitMaltaUSA

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