Rheumaderm pp 187-191 | Cite as

Dermatomyositis and Drugs

  • Assen L. Dourmishev
  • L. A. Dourmishev
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 455)


Dermatomyositis (DM) is an idiopathic inflammatory disorder consisting of skin and skeletal muscle involvement. Patients with skeletal muscle involvement have polymyositis (PM), and those unresponsive to therapy and with characteristic findings on muscle biopsy have inclusion body myositis. Patients without muscle damage and typical skin lesions have amyopathic dermatomyositis. Disease in children (juvenile dermatomyositis) is not associated with malignancy as it may be in adults (paraneoplastic dermatomyositis). Overlap syndrome (OS) is mixed connective tissue disease combining some features of DM, SS and LES. Scleromyositis is overlap syndrome associated with anti-PM-Scl antibodies. Patients with PM, DM or OS with “interstitial lung disease” and anti-synthetase antibodies have an “anti-synthetase syndrome”. Various drugs, including d-penicillamine, NSAIDs, anti-infectious agents, as well as lipid lowering drugs, the HMG-CoA reductase inhibitors may cause myopathy and skin lesions (drug induced dermatomyositis). “Dermatomyositis” occurring as adverse reactions of drugs are rare, irregular and impossible to predict in individual patients. They are very interesting in that they may be keys for explaining the pathogenic mechanisms of the disease.


Interstitial Lung Disease Inclusion Body Myositis Zidovudine Therapy Juvenile Dermatomyositis Systemic Scleroderma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Assen L. Dourmishev
    • 1
  • L. A. Dourmishev
    • 1
  1. 1.Department of DermatologyUniversity of MedicineSofiaBulgaria

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