Abstract
The SLE database at the Rheumatology Clinic, St. Luke’s Hospital currently includes 62 patients. The presentation, clinical features, ACR criteria and laboratory findings in RNP positive lupus patients [14] were compared to RNP negative subgroup [33].
RNP positivity was significantly associated with Raynaud’s phenomenon (p<0.01), myalgia (p<0.02), myositis (p<0.05), neuropsychiatric features (p<0.05) and Sm positivity (p<0.01).
RNP positive patients had a higher frequency of positive family history, mortality, malar and maculopapular rashes, nail-fold infarcts, telangiectasia, digital vasculitis, photo-sensitivity, arthritis, pleurisy, pericarditis, pericardial effusions, depression, headache, psychosis and TIA.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cervera R, Khamashta MA, Font J et al. Systemic lupus erythematosus: clinical and immunological patterns of disease expression in a cohort of 1000 patients. Medicine 72: 113–24. 1993.
Tan EM, Cohen AS, Fries JF, et al The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25: 1271–1277. 1982.
Montecucco et al. Frequency and clinical significance of anti-RNP antibodies in Italian SLE patients. Annals-Ital-Med-Int. 9(1): 12–15. 1994.
Thompson D. et al. The clinical significance of autoantibody profiles in patients with systemic lupus erythematosus. Lupus 2(1): 15–19. 1993.
Tikly M. et al. Autoantibodies in black South Africans with systemic lupus erythematosus: spectrum and clinical associations. Clinical Rheumatology 15(3): 261–265. 1996.
Swaak AJ et al. Antinuclear antibodies in routine analysis: the relevance of putative clinical associations. Ann. Rheum. Diseases 52(2): 110–114. 1993.
Gulko PS et al. Survival impact of autoantibodies in systemic lupus erythematosus. Journal of Rheumatology 21(2): 224–228. 1994.
Vanveenrooij et al. Small nuclear RNA-associated proteins: autoantigens in connective tissue diseases. Clin Exp Rheumatology 7: 635–639. 1989.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media New York
About this chapter
Cite this chapter
Camilleri, F., Mallia, C. (1999). RNP Positivity in Maltese SLE Patients. In: Mallia, C., Uitto, J. (eds) Rheumaderm. Advances in Experimental Medicine and Biology, vol 455. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4857-7_23
Download citation
DOI: https://doi.org/10.1007/978-1-4615-4857-7_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7203-5
Online ISBN: 978-1-4615-4857-7
eBook Packages: Springer Book Archive