RNP Positivity in Maltese SLE Patients
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 455)
The SLE database at the Rheumatology Clinic, St. Luke’s Hospital currently includes 62 patients. The presentation, clinical features, ACR criteria and laboratory findings in RNP positive lupus patients  were compared to RNP negative subgroup .
RNP positivity was significantly associated with Raynaud’s phenomenon (p<0.01), myalgia (p<0.02), myositis (p<0.05), neuropsychiatric features (p<0.05) and Sm positivity (p<0.01).
RNP positive patients had a higher frequency of positive family history, mortality, malar and maculopapular rashes, nail-fold infarcts, telangiectasia, digital vasculitis, photo-sensitivity, arthritis, pleurisy, pericarditis, pericardial effusions, depression, headache, psychosis and TIA.
KeywordsSystemic Lupus Erythematosus Connective Tissue Disease Positive Family History Pericardial Effusion Maculopapular Rash
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Cervera R, Khamashta MA, Font J et al. Systemic lupus erythematosus: clinical and immunological patterns of disease expression in a cohort of 1000 patients. Medicine 72: 113–24. 1993.PubMedCrossRefGoogle Scholar
Tan EM, Cohen AS, Fries JF, et al The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25: 1271–1277. 1982.PubMedCrossRefGoogle Scholar
Montecucco et al. Frequency and clinical significance of anti-RNP antibodies in Italian SLE patients. Annals-Ital-Med-Int. 9(1): 12–15. 1994.Google Scholar
Thompson D. et al. The clinical significance of autoantibody profiles in patients with systemic lupus erythematosus. Lupus 2(1): 15–19. 1993.PubMedGoogle Scholar
Tikly M. et al. Autoantibodies in black South Africans with systemic lupus erythematosus: spectrum and clinical associations. Clinical Rheumatology 15(3): 261–265. 1996.PubMedCrossRefGoogle Scholar
Swaak AJ et al. Antinuclear antibodies in routine analysis: the relevance of putative clinical associations. Ann. Rheum. Diseases 52(2): 110–114. 1993.CrossRefGoogle Scholar
Gulko PS et al. Survival impact of autoantibodies in systemic lupus erythematosus. Journal of Rheumatology 21(2): 224–228. 1994.PubMedGoogle Scholar
Vanveenrooij et al. Small nuclear RNA-associated proteins: autoantigens in connective tissue diseases. Clin Exp Rheumatology 7: 635–639. 1989.Google Scholar
© Springer Science+Business Media New York 1999