Rheumaderm pp 115-125 | Cite as

Cutaneous Necrotizing Vasculitis

Relation to Systemic Disease
  • Torello M. Lotti
  • C. Comacchi
  • I. Ghersetich
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 455)


Cutaneous necrotizing vasculitis (CNV) is a complex multisystem disease generally involving the skin and mucous membranes, often accompanied by renal, gastrointestinal, pericardial, neurological, and articular signs and symptoms. CNV may be idiopatical or occur in association with a drug, infection, or underlyng disease.

CNV has been shown in patients with chronic infections (viral, bacterial, protozoa, helminthic), serum sickness, a variety of collagen vascular diseases (systemic lupus erythematous, Sjögren’s syndrome, rheumatoid arthritis, Behçet’s disease) hyperglobulinemic states, cryoglobulinemia, bowel bypass syndrome, ulcerative colitis, cystic fibrosis, primary biliary cirrhosis and HIV infection. Association with malignancies is not frequent. Lympho- proliferative disorders (Hodgkin’s disease, mycosis fungoides, lymphosarcoma, adult T-cell leukemia, multiple mieloma) and solid tumors (lung cancer, colon carcinoma, renal, prostate, head and neck cancer and breast cancer) may be associated with CNV Whenever possible, treatment is directed at the elimination of the cause. In other cases after adequate laboratory screening local and systemic therapy are recommended.


Primary Biliary Cirrhosis Mycosis Fungoides Systemic Lupus Erythematous Serum Sickness Leukocytoclastic Vasculitis 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Torello M. Lotti
    • 1
  • C. Comacchi
    • 1
  • I. Ghersetich
    • 1
  1. 1.Department of DermatologyUniversity of FlorenceFlorenceItaly

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