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Rheumaderm pp 105-109 | Cite as

Scleroderma Profunda

Clinicopathological Studies
  • Maria Balabanova
  • E. Obreshkova
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 455)

Abstract

Scleroderma profunda represents an unusual clinical entity. There are no unified criteria for its diagnosis. Seven patients with scleroderma profunda were studied. The clinical features can be summarised in three groups:
  1. 1.

    hyperpigmented plaques with subcutaneous induration;

     
  2. 2.

    erythematous plaques with induration of the skin and subcutis;

     
  3. 3.

    pale indurated plaques with atrophy and sometimes ulcerobullous lesions.

     

Histology showed sclerodermiform changes in the deep dermis and subcutis and vasculitis in one case. Dermal lymphocytic infiltration was well pronounced in 5 cases and consisted of predominantly CD3+ T cells. Differential diagnosis from panniculitis can be difficult. Mucin deposition was established in all cases.

Keywords

Collagen Bundle Lichen Sclerosis Papillary Dermis Tissue Eosinophilia Erythematous Plaque 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Su WPD. Morphea profunda. 14th Colloquium of the International Society of Dermatopathology. Siena June26–July 1, 1993.Google Scholar
  2. 2.
    Whittaker SJ, Smith NP, Russel-Jones R. Solitary morphea profunda. Br J Dermatol. 120: 431–440 (1989).PubMedCrossRefGoogle Scholar
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    Fleischmajer R, Nedwich A. Generalized morphoea. Arch Dermatol. 106: 509–514 (1972).PubMedCrossRefGoogle Scholar
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    Person JR, Su D. Subcutaneous morphoea. Br J Dermatol. 100: 371–380 (1979).PubMedCrossRefGoogle Scholar
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    Su D, Person JR. Morphoea profunda. Am J Dermatopathol. 3: 251–260 (1981).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Maria Balabanova
    • 1
  • E. Obreshkova
    • 1
  1. 1.Department of DermatologyMedical UniversitySofiaBulgaria

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