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Aging and Degenerative Diseases

A Mitochondrial Paradigm

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Book cover Frontiers of Cellular Bioenergetics

Abstract

Over the past 9 years, a large number of mitochondrial DNA (mtDNA) mutations have been linked to human degenerative diseases. Clinical manifestations that have been identified in mtDNA disease patients include vision loss, deafness, dementia, movement disorders, seizures, strokes, myopathy, cardiomyopathy, endocrine disorders, and renal failure. One of the striking features of many mtDNA diseases is that they have a delayed onset and progressive course and that many of the symptoms seen in mitochondrial disease patients are also common features of the aging process. This has led to the hypothesis that many of the age-related degenerative diseases of humans as well as aging itself are related to defects in the mitochondrial bioenergetic pathway: oxidative phosphorylation (OXPHOS) (Wallace, 1992a, 1992b, 1994, 1995, 1997).

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  1. Center for Molecular Medicine, Emory University School of Medicine, Atlanta, Georgia, 30322, USA

    Douglas C. Wallace

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  1. University of Bari, Bari, Italy

    Sergio Papa  & Ferruccio Guerrieri  & 

  2. University of Amsterdam, Amsterdam, The Netherlands

    Joseph M. Tager

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Wallace, D.C. (1999). Aging and Degenerative Diseases. In: Papa, S., Guerrieri, F., Tager, J.M. (eds) Frontiers of Cellular Bioenergetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4843-0_30

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  • DOI: https://doi.org/10.1007/978-1-4615-4843-0_30

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