Abstract
The retinal projection to the lateral geniculate nucleus (LGN) of the thalamus (the “retinogeniculate projection”) has become an ideal system for studying activity- dependent neural development. As the primary visual pathway to the cortex it is well studied, and it develops complex structures under the influence of spontaneous activity. Three models of development in the retinogeniculate system have been suggested.1,2,3 None of these models encompasses the full range of structural refinement in the system and none considers the physiological development of LGN neurons. This paper attempts to provided a cohesive, realistic, and biologically predictive framework in which to investigate the development of retinotopy, eye-specific layers and on/off sub-layers in the retinogeniculate projection. A brief introduction to the biological system will help situate the model.
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Haith, G.L., Heeger, D. (1998). A Computational Model of Retinogeniculate Development. In: Bower, J.M. (eds) Computational Neuroscience. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4831-7_6
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DOI: https://doi.org/10.1007/978-1-4615-4831-7_6
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