Abstract
Stimulation of metabotropic glutamate receptors (mGluRs) triggers release of Ca 2+ from intracellular stores through activation of the phospholipase C (PLC)→ inositol (l, 4, 5)-trisphosphate (IP3) cascade (figure 1). Recent experiments have shown that the exact pattern of the Ca 2+ response depends on the mGluR subtype.1 Glutamate stimulation of the mGluR5a subtype results in damped Ca 2+ oscillations, whereas stimulation of the mGluRlα subtype causes a single-peaked response (figure 2). Given that the mGluR5a (but not the mGluRlα) subtype is a substrate for phosphorylation by protein kinase C (PKC), this indicates that the oscillations are generated by inactivation of the receptors by Ca 2+ dependent PKC phosphorylation.
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Steuber, V., Willshaw, D.J. (1998). Modelling the Control of Calcium Oscillations by Phosphorylation of Metabotropic Glutamate Receptors. In: Bower, J.M. (eds) Computational Neuroscience. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4831-7_46
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DOI: https://doi.org/10.1007/978-1-4615-4831-7_46
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