Abstract
A model of a dentate granule cell that explicitly included all dendritic spines was used to explore the relative contributions of voltage-gated calcium channels and NMDA receptor channels to calcium influx in dendritic spines following tetanic stimulation. Up to 10 T, N, or L calcium channels were placed in each dendritic spine. It was found that calcium currents through calcium channels in spines had a much shorter duration than the NMDA calcium current, except for T channels, and had an amplitude that was in many cases comparable in magnitude to the NMDA calcium current.
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References
D.B. Jaffe, S.A. Fisher and T.H. Brown, Confocal laser scanning microscopy reveals voltage-gated calcium signals within hippocampal dendritic spines, J. Neurobiol. 25: 220–233 (1993).
R.C. Malenka and R.A. Nicoll, NMDA-receptor-dependent synaptic plasticity: Multiple forms and mechanisms, Trends Neurosci. 16: 521–527(1993).
J.M. Bower and D. Beeman. The Book of GENESIS: Exploring Neural Models with the GEneral NEural Simulation System, Telos Springer, Santa Clara, CA (1995).
G.L.F. Yuen and D. Durand, Reconstruction of hippocampal granule cell electrophysiology by computer simulation, Neuroscience 41: 411–423 (1991).
D.B. Jaffe, W.N. Ross, J.E. Lisman, N. Lasser-Ross, H. Miakawa and D. Johnston, Model for dendritic Ca2+ accumulation in hippocampal pyramidal neurons based on fluorescence imaging measurements, J. Neurophysiol. 71: 1065–1077 (1994).
E.N. Warman, D.M. Durand and G.L.F. Yuen, Reconstruction of hippocampal CA1 pyramidal cell electrophysiology by computer simulation, J. Neurophysiol. 71: 2033–2045 (1994).
E. DeSchutter and J.M. Bower, An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice, J. Neurophysiol. 71: 375–400 (1994).
K.J. Staley, T.S. Otis, and I. Mody, Membrane properties of dentate gyrus granule cells: Comparison of sharp microelectrode and whole-cell recordings, J. Neurophysiol. 67: 1346–1358 (1992).
N. Spruston and D. Johnston, Perforated patch-clamp analysis of the passive membrane properties of three classes of hippocampal neurons, J. Neurophysiol. 67: 508–529 (1992).
L. Zhang, T.A. Valiante and P.L. Carlen, Contribution of the low-threshold T-type calcium current in generating the post-spike depolarizing afterpotential in dentate granule neurons of immature rats, J. Neurophysiol. 70: 223–231 (1993).
W.R. Holmes and W.B. Levy, Quantifying the role of inhibition in associative long-term potentiation in dentate granule cells with computational models, J. Neurophysiol. 78: 103–116 (1997).
W.R. Holmes and W.B. Levy, Insights into associative long-term potentiation from computational models of NMD A receptor-mediated calcium influx and intracellular calcium concentration changes, J. Neurophysiol. 63: 1148–1168 (1990).
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© 1998 Springer Science+Business Media New York
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Holmes, W.R., Aradi, I. (1998). Modeling the Contributions of Calcium Channels and NMDA Receptor Channels to Calcium Current in Dendritic Spines. In: Bower, J.M. (eds) Computational Neuroscience. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4831-7_32
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DOI: https://doi.org/10.1007/978-1-4615-4831-7_32
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