Abstract
Ryanodine receptor-mediated calcium release was modeled in a compartmental model of the Purkinje cell with a detailed representation of buffered calcium diffusion. For several important parameters no constraining experimental data were available. The importance of the threshold of activation of release and of the unbinding rate of the main calcium buffer in the stores (calsequestrin) is described. Using reasonable assumptions for these parameters, calcium influx during voltage-gated calcium spikes can activate ryanodine receptors in the submembrane region without noticeably changing the firing pattern of the model.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
M.E. Martone, Y. Zhang, V.M. Simpliciano, B.O. Carragher, and M.H. Ellisman, Three-dimensional visualization of the smooth endoplasmatic reticulum in Purkinje cell dendrites, J. Neurosci 13: 4636 (1993).
I. Llano, J. Dreessen, M. Kano, and A. Konnerth, Intradendritic release of calcium induced by glutamate in cerebellar Purkinje cells, Neuron 7: 577 (1991).
I. Llano, R. DiPolo, and A. Marty, Calcium-induced calcium release in cerebellar Purkinje cells, Neuron 12: 663(1994).
M. Kano, O. Garaschuk, A. Verkhratsky, and A. Konnerth, Ryanodine receptor-mediated intracellular calcium release in rat cerebellar Purkinje neurones, J. Physiol. 487: 1 (1995).
E. De Schutter, and J.M. Bower, An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice., J. Neurophysiol. 71: 375 (1994).
E. De Schutter, and P. Smolen, Calcium dynamics in large neuronal models in Methods in Neuronal Modeling: from Synapses to Networks, C. Koch, and I. Segev, eds., MIT Press, Cambridge, MA (1998).
M.L. Albritton, T. Meyer, and L. Stryer, Range of messenger action of calcium ion and inositol 1, 4, 5-triphosphate, Science 258: 1812 (1992).
L. Fierro, and I. Llano, High endogenous calcium buffering in Purkinje cells from rat cerebellar slices, J. Physiol 496: 617(1996).
H. Blumenfeld, L. Zablow, and B. Sabatini, Evaluation of cellular mechanisms for modulation of calcium transients using a mathematical model of fura-2 Ca2+ imaging in Aplysia sensory neurons, Biophys. 7 63: 1146(1992).
S.L. Palay, and V. Chan-Palay. Cerebellar Cortex, Springer-Verlag, New York (1974).
A. Goldbeter, G. Dupont and M.J. Berridge, Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation, Proc. Natl. Acad. Sci. USA 87: 1461 (1990).
S. Györke, and M. Fill, Ryanodine receptor adaptation: control mechanism of Ca2+-induced Ca2+ release in heart, Science 260: 807 (1993).
J. Sneyd, A.C. Charles, and M.J. Sanderson, A model for the propagation of intracellular calcium waves, Amer. J. Physiol. 266: C293–C302 (1994).
T.R. Cheek, M.J. Berridge, R.B. Moreton, K.A. Stauderman, M.M. Murawsky, and M.D. Bootman, Quantal Ca2+ mobilization by ryanodine receptors is due to all-or-none release from functionally discrete intracellular stores, Biochem. J. 301: 879 (1994).
F. Baba-Aissa, L. Raeymaekers, F. Wuytack, G. Callewaert, L. Dode, L. Missiaen, and R. Casteels, Purkinje neurons express the SERCA3 isoform of the organellar type Ca2+-transport ATPase, Molec. Brain Res. 41: 169(1996).
N. Ikemoto, M. Ronjat, L.G. Mészáros, and M. Koshita, Postulated role of calsequestrin in the regulation of calcium release from sarcoplasmic reticulum, Biochemistry 28: 6764 (1989).
J.R. Brorson, D. Bleakman, S.J. Gibbons, and RJ. Miller, The properties of intracellular calcium stores in cultured rat cerebellar neurons, J. Neurosci. 11: 4024 (1991).
R.R. Llinás, and M. Sugimori, Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices, / Physiol. 305: 171 (1980).
Y.M. Usachev, and S.A. Thayer, All-or-none Ca2+ release from intracellular stores triggered by Ca2+ influx through voltage-gated Ca2+ channels in rat sensory neurons, J. Neurosci. 17: 7404 (1997).
E. De Schutter, Modelling the cerebellar Purkinje cell: Experiments in computo, Prog. Brain Res. 102: 427(1994).
D. Jaeger, E. De Schutter, and J.M. Bower, The role of synaptic and voltage-gated currents in the control of Purkinje cell spiking: a modeling study, J. Neurosci. 17: 91 (1997).
D. Jaeger, and J.M. Bower, The function of background synaptic input in cerebellar Purkinje cells explored with dynamic current clamping, Abstr. Soc. Neurosci. 22: 494 (1996).
E. De Schutter, and J.M. Bower, Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs, Proc. Natl. Acad. Sci. USA 91: 4736 (1994).
J. Eilers, G.J. Augustine, and A. Konnerth, Subthreshold synaptic Ca2+ signaling in fine dendrites and spines of cerebellar Purkinje neurons, Nature 373: 155 (1995).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
De Schutter, E. (1998). Detailed Model of Ryanodine Receptor-Mediated Calcium Release in Purkinje Cells. In: Bower, J.M. (eds) Computational Neuroscience. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4831-7_27
Download citation
DOI: https://doi.org/10.1007/978-1-4615-4831-7_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7190-8
Online ISBN: 978-1-4615-4831-7
eBook Packages: Springer Book Archive