Abstract
Treatment response/drug resistance in childhood acute lymphoblastic leukaemia (ALL) is related to presenting white cell count. This relationship might be explained by high proliferation fraction or by absence of significant apoptosis, but is presently unknown.
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References
Liptay S, Seriu T, Bartram CR, Schmid RM. Germline configuration of nfkb2, c-rel and bc13 in childhood acute lymphoblastic leukaemia (ALL). Leukaemia, 1977, 11:1364–1366.
Salomons GS, Brady HG, Verwijs-Janssen M, van den Bergh JD, et al. The Bax alpha: Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood leukaemia. Intern J Cancer 1997, 71:959–965.
Uckun FM, Yang Z, Sather H, Steinherz P, et al. Cellular expression of anti-apoptotic Bcl2 oncoprotein in newly diagnosed childhood acute lymphoblastic leukaemia: a Childrens Cancer Group study. Blood, 1997, 89:3769–3777.
Tsangaris GT, Moschovi M, Mikraki V, et al. Study of apoptosis in peripheral blood of patients with acute lymphoblastic leukaemia during induction therapy. Anticancer Res 1996, 16:3133–3140.
Coustan-Smith E, Kitenaka A, Pui CH, McNinch L, et al. Clinical relevance of Bcl2 overexpression in childhood acute lymphoblastic leukaemia. Blood, 1996, 87:1140–1146.
Thiele J, Zirbes TK, Lorenzen J, Kvasnicka HM, et al. Haemopoietic turnover index in reactive and neoplastic bone marrow lesions quantification by apoptosis and PCNA labelling. Ann Haematol, 1997, 75:33–39.
Wyllie AH. Apoptosis and regulation of cell numbers in normal and neoplastic tissues: an overview. Cancer Met Rev 1992, 11:95–103.
Hicsonmez G, Erdemli E, Tekelioglu M, Tuncer AM, et al. Morphological evidence of apoptosis in childhood acute myeloblastic leukaemia treated with high dose methyl prednisolone. Leuk Lymphoma, 1996, 22:91–96.
Debatin KM, Krammer PH. Resistance to Apo1(CD95) induced apoptosis in T-ALL is determined by Bcl2 independent ati-apoptotic program. Leukaemia, 1995, 9:815–820.
Baxter GD, Collins RJ, Harmon BV, Kumar S, et al. Cell death by apoptosis in acute leukaemia. J Pathol, 1989, 158:123–129.
Findley HW, Gu L, Yeager AM, Zhou M. Expression and regulation of Bcl2, Bcl-xl and Bax correlates with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukaemia. Blood, 1997, 89:2986–2993.
Tsangaris GT, Tzortzatou-Stathopoulou F. Development of a quantitative method for the study of apoptosis in peripheral blood. In Vivo, 1996, 10:435–443.
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© 1999 Springer Science+Business Media New York
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Pyesmany, A.F. et al. (1999). Proliferation and Apoptosis Does Not Affect Presenting White Cell Count in Childhood All. In: Kaspers, G.J.L., Pieters, R., Veerman, A.J.P. (eds) Drug Resistance in Leukemia and Lymphoma III. Advances in Experimental Medicine and Biology, vol 457. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4811-9_33
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DOI: https://doi.org/10.1007/978-1-4615-4811-9_33
Publisher Name: Springer, Boston, MA
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