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MRP Expression in Acute Myeloid Leukemia

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Drug Resistance in Leukemia and Lymphoma III

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 457))

Abstract

To determine the clinical significance of the multidrug resistance protein (MRP) in patients with de novo AML, we have studied MRP expression of leukemic cells at diagnosis and its association with clinical outcome in 127 patients. MRP expression was determined by immunocytochemistry by means of monoclonal antibodies QCRL-l/QCRL-3. MRP expression was low, intermediate and high in 30%, 46% and 24% of the patients, respectively. MRP expression was independent of age and sex of the patients, white blood cell count, FAB subtype, serum lactate dehydrogenase levels and karyotype aberrations. MRP expression had no impact on response to induction chemotherapy. The complete remission rates were 75%, 70% and 64% for patients with low, intermediate and high expression, respectively. Patients with intermediate or high MRP expression showed a trend toward shorter overall survival (p=0.09) as compared to patients with low MRP expression. MRP does not predict for response to induction chemotherapy but intermediate or high MRP expression might be associated with shorter overall survival of the patients.

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Authors and Affiliations

  1. Divisions of Oncology and Hematology Department of Internal Medicine I, University of Vienna Medical School, Währinger Gürtel 18, A-1090, Vienna, Austria

    Martin Filipits, Thomas Stranzl, Gudrun Pohl, Ralf W. Suchomel, Sabine Zöchbauer, Raoul Brunner, Klaus Lechner & Robert Pirker

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  1. Martin Filipits
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  2. Thomas Stranzl
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  3. Gudrun Pohl
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  4. Ralf W. Suchomel
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  5. Sabine Zöchbauer
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  6. Raoul Brunner
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  7. Klaus Lechner
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  8. Robert Pirker
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Editors and Affiliations

  1. University Hospital Vrije Universiteit, Amsterdam, The Netherlands

    G. J. L. Kaspers , R. Pieters  & A. J. P. Veerman ,  & 

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© 1999 Springer Science+Business Media New York

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Filipits, M. et al. (1999). MRP Expression in Acute Myeloid Leukemia. In: Kaspers, G.J.L., Pieters, R., Veerman, A.J.P. (eds) Drug Resistance in Leukemia and Lymphoma III. Advances in Experimental Medicine and Biology, vol 457. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4811-9_16

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  • DOI: https://doi.org/10.1007/978-1-4615-4811-9_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7180-9

  • Online ISBN: 978-1-4615-4811-9

  • eBook Packages: Springer Book Archive

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