Abstract
Asymmetric Mannich-type reactions provide useful routes for the synthesis of optically active β-amino ketones or esters, which are versatile chiral building blocks in the preparation of many nitrogen-containing biologically important compounds. While several diastereoselective Mannich-type reactions have already been reported, very little is known about the enantioselective versions. In addition, asymmetric Mannich-type reactions using small amounts of chiral sources have not been reported, when we started these research efforts.
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References and Notes
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Kobayashi, S. (1999). Catalytic Enantioselective Reactions of Aldimines Using Chiral Lewis Acids. In: Scolastico, C., Nicotra, F. (eds) Current Trends in Organic Synthesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4801-0_23
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DOI: https://doi.org/10.1007/978-1-4615-4801-0_23
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