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Iron and Erythropoiesis

Lessons from Anemic Mice

  • Chapter
Molecular Biology of Hematopoiesis 6

Abstract

Iron deficiency and iron overload disorders are among the most common diseases afflicting modern man. Iron deficiency affects up to one billion individuals worldwide. Women and children are most commonly iron deficient, as a result of increased iron needs attributable to regular blood loss and rapid growth, respectively. Untreated iron deficiency in infants and toddlers can lead to irreversible cognitive deficits. Internationally, most iron deficiency can be traced to dietary insufficiency or subacute gastrointestinal hemorrhage associated with chronic parasitic infections. Rare patients have inherited defects in iron absorption or iron utilization. Iron deficiency is usually treatable with oral iron salts. While this treatment is inexpensive, it may be difficult to achieve compliance, because iron repletion takes several months to complete.

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Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute and Division of Hematology/Oncology, Children’s Hospital, USA

    Nancy C. Andrews & Mark D. Fleming

  2. Departments of Pathology and Pediatrics, Harvard Medical School, Boston, MA, USA

    Nancy C. Andrews & Mark D. Fleming

Authors
  1. Nancy C. Andrews
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  2. Mark D. Fleming
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Editor information

Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    Nader G. Abraham

  2. University of Perugia, Perugia, Italy

    Antonio Tabilio  & Massimo Martelli  & 

  3. University of Tokyo, Tokyo, Japan

    Shigetaka Asano

  4. Bambino Gesu Hospital, Rome, Italy

    Alberto Donfrancesco

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© 1999 Springer Science+Business Media New York

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Andrews, N.C., Fleming, M.D. (1999). Iron and Erythropoiesis. In: Abraham, N.G., Tabilio, A., Martelli, M., Asano, S., Donfrancesco, A. (eds) Molecular Biology of Hematopoiesis 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4797-6_44

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  • DOI: https://doi.org/10.1007/978-1-4615-4797-6_44

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7173-1

  • Online ISBN: 978-1-4615-4797-6

  • eBook Packages: Springer Book Archive

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