Abstract
Megakaryocytopoiesis is a perplexing enigmatic process dependent on both early and late-acting hematopoietic growth factors. The proliferation and maturation steps of this process are regulated by lineage non-specific megakaryocytopoietic cytokines and thrombopoietin (TPO).1,2 TPO is the most critical cytokine regulator of platelet production and maturation. Likewise, Interleukin-6 (IL-6) has the most potent thrombopoietic activity of any agent except thrombopoietin and likely to have a physiological role in this process.3
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Haznedaroğlu, İ.C., Büyükaşik, Y., Koşar, A., Özcebe, O.İ., Kirazli, Ş., Dündar, S.V. (1999). Cytokines, Thrombopoietin, and Selectins in Immune Thrombocytopenic Purpura. In: Abraham, N.G., Tabilio, A., Martelli, M., Asano, S., Donfrancesco, A. (eds) Molecular Biology of Hematopoiesis 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4797-6_27
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DOI: https://doi.org/10.1007/978-1-4615-4797-6_27
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