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The Development of Hematopoietic Cell Transplantation and its Application to Organ Transplantation and Autoimmune Diseases

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Molecular Biology of Hematopoiesis 6

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Abstract

Jacobson,1 in the course of studies of radiation biology, found that shielding the spleen of a mouse during otherwise lethal irradiation permitted survival. Subsequently, Lorenz et al.2 found that irradiated mice could be protected by an infusion of spleen or marrow cells. Confirmation that the“irradiation protection” phenomenon was due to reconstitution by donor cells came from the observation of Main and Prehn3 that irradiated mice protected by an infusion of allogeneic marrow subsequently displayed tolerance of a donor skin graft. Their observation was followed shortly by the report of Ford et al.4 that the marrow of such animals had the cytogenetic characteristics of the marrow donor.

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Authors
  1. E. Donnall Thomas
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Editor information

Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    Nader G. Abraham

  2. University of Perugia, Perugia, Italy

    Antonio Tabilio  & Massimo Martelli  & 

  3. University of Tokyo, Tokyo, Japan

    Shigetaka Asano

  4. Bambino Gesu Hospital, Rome, Italy

    Alberto Donfrancesco

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© 1999 Springer Science+Business Media New York

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Thomas, E.D. (1999). The Development of Hematopoietic Cell Transplantation and its Application to Organ Transplantation and Autoimmune Diseases. In: Abraham, N.G., Tabilio, A., Martelli, M., Asano, S., Donfrancesco, A. (eds) Molecular Biology of Hematopoiesis 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4797-6_1

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  • DOI: https://doi.org/10.1007/978-1-4615-4797-6_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7173-1

  • Online ISBN: 978-1-4615-4797-6

  • eBook Packages: Springer Book Archive

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